Results 131 to 140 of about 6,529,508 (347)

Evaluation of sample preparation approaches and separation parameters in HPLC of plant bioactive compounds

, 2015
Plant bioactive compounds can be defined as secondary plant metabolites produced within the plants besides the primary biosynthetic and metabolic routes.
Isabella Nicoletti, Danilo Corradini, Francesca Orsini, Laura De Gara   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on Separation Density of Feeding Group Particle in the Gas–Solid Separation Fluidized Bed

Gas–solid separation fluidized bed is an efficient coal cleaning and separation technology, and this technology has been extensively used in coal separation. The separation of the feeding coal particles in the fluidized bed is generally carried out
Xuchen Fan, Yuping Fu, Liying Sun, Yijiang Li, Yongliang He   +4 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo

Dynamic chromosome remodeling and nuclear compartmentalization take place during mammalian meiotic prophase I. We report here that the crucial roles of male pachynema-specific protein (MAPS) in pachynema progression might be mediated by its liquid-liquid
Yeung, William SB, Li, Zheng, Rodriguez-Wallberg, Kenny A, Zhao, Yu, Chow, Louise T, Yao, Chencheng, Liu, Dongteng, Li, Dongliang, Zhang, Hao, Cao, Dandan, Shi, Fu, Feng, Haiwei, Wang, Hengbin, Chen, Chunxu, Hu, Zhe, Zhang, Yuxiang, Liu, Kui, Li, Peng, Zheng, Jiahuan, Lin, Zexiong, Jiang, Binjie   +20 more
core   +1 more source

Kinetic Management of Vertical Phase Separation via Thermal Annealed Donor‐Assisted Sequential Deposition Enables 20.81% Efficiency in Organic Solar Cells [PDF]

Shizhao Liu, Fan Feng, Wentao Zou, Xuanqing Cao, Yuanyuan Kan, Huajun Xu, Xunchang Wang, Jianan Zheng, Shengnan Liu, Xianshao Zou, Guangye Zhang, Xichang Bao, Renqiang Yang, Yanna Sun, Ke Gao   +14 more
openalex   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales. [PDF]

Proc Natl Acad Sci U S A, 2022
Gaday Q, Megrian D, Carloni G, Martinez M, Sokolova B, Ben Assaya M, Legrand P, Brûlé S, Haouz A, Wehenkel AM, Alzari PM.   +10 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source