Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Multiple-Streams Focusing-Based Cell Separation in High Viscoelasticity Flow. [PDF]
ACS Omega, 2022 Feng H +5 more
europepmc +1 more source
Differential electrophoretic separation of cells and its effect on cell viability [PDF]
An electrophoretic separation method was applied to the separation of cells. To determine the efficiency of the separation, it was necessary to apply existing methodology and develop new methods to assess the characteristics and functions of the ...
Leise, E. M., Lesane, F.
core +1 more source
Functional Separation of the Na-K Exchange Pump from the Volume Controlling Mechanism in Enlarged Duck Red Cells [PDF]
, 1974 Floyd M. Kregenow
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Inertia-Acoustophoresis Hybrid Microfluidic Device for Rapid and Efficient Cell Separation. [PDF]
Sensors (Basel), 2022 Kim U, Oh B, Ahn J, Lee S, Cho Y.
europepmc +1 more source
Fermi liquid viscosity in a finite geometry [PDF]
Forced flow of a Fermi liquid is studied for a cell geometry consisting of two planes with a separation on the order of mean free path. An approximate transport equation is used to derive an integral equation for the velocity profile, which is solved ...
Jaffe, J. E.
core +1 more source
Comparison of Gas Membrane Separation Cascades Using Conventional Separation Cell and Two-Unit Separation Cells [PDF]
, 1978 M. Ohno +3 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
A moonlighting role for LysM peptidoglycan binding domains underpins Enterococcus faecalis daughter cell separation. [PDF]
Commun Biol, 2023 Salamaga B +5 more
europepmc +1 more source