Results 231 to 240 of about 827,991 (338)

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Protocol for isolating high-purity natural killer cells from peripheral blood of septic patients using magnetic cell separation. [PDF]

STAR Protoc
Coulibaly A, Sturm T, Schulte J, Lindner HA, Velásquez SY.   +4 more
europepmc   +1 more source

Autophagy promotes organelle clearance and organized cell separation of living root cap cells in Arabidopsis thaliana.

Development, 2022
Goh T, Sakamoto K, Wang P, Kozono S, Ueno K, Miyashima S, Toyokura K, Fukaki H, Kang BH, Nakajima K.   +9 more
europepmc   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Separation of Specific Antibody-Forming Mouse Cells by their Adherence to Insolubilized Endogenous Hormones

, 1974
Kenneth L. Melmon, Yacob Weinstein, G M Shearer, Henry R. Bourne, S. Bauminger   +4 more
openalex   +1 more source

Separation and isolation of rat natural killer (NK) cells from T cells with monoclonal antibodies. [PDF]

, 1984
BA Woda, Mary L. McFadden, Raymond M. Welsh, Kathleen Bain   +3 more
openalex   +1 more source

Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in Escherichia coli under acidic stress. [PDF]

Antimicrob Agents Chemother
Son JE, Park SH, Choi U, Lee C-R.
europepmc   +1 more source

Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis. [PDF]

Mol Biol Cell, 2021
Poddar A, Sidibe O, Ray A, Chen Q.
europepmc   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source