Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Development of 2D Microfluidics Surface with Low-Frequency Electric Fields for Cell Separation Applications. [PDF]
Sensors (Basel)Wickramasinghe M, Nawarathna D.
europepmc +1 more source
Multichannel impedance cytometry downstream of cell separation by deterministic lateral displacement to quantify macrophage enrichment in heterogeneous samples. [PDF]
Adv Mater Technol, 2023 Torres-Castro K +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
An activator of a two-component system controls cell separation and intrinsic drug resistance in <i><i>Mycobacterium tuberculosis</i></i>. [PDF]
Proc Natl Acad Sci U S AMcDonough LD +5 more
europepmc +1 more source
Impact of buffer composition on biochemical, morphological and mechanical parameters: A tare before dielectrophoretic cell separation and isolation. [PDF]
Transl Oncol, 2023 Bonacci PG +8 more
europepmc +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Validation of a New High-Throughput Cell Separation Method for Downstream Molecular Applications. [PDF]
Int J Mol SciShillingford D +5 more
europepmc +1 more source
Design and Development of a Traveling Wave Ferro-Microfluidic Device and System Rig for Potential Magnetophoretic Cell Separation and Sorting in a Water-Based Ferrofluid. [PDF]
Micromachines (Basel), 2023 Hewlin RL, Edwards M, Schultz C.
europepmc +1 more source