Results 111 to 120 of about 1,875,893 (398)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

eLife, 2019
When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes.
Madison Bolger-Munro, Kate Choi, Joshua M Scurll, Libin Abraham, Rhys S Chappell, Duke Sheen, May Dang-Lawson, Xufeng Wu, John J Priatel, Daniel Coombs, John A Hammer, Michael R Gold   +11 more
doaj   +1 more source

Cancer biomarkers, and novel techniques for detection [PDF]

, 2017
Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core  

B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production. [PDF]

, 2016
A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM.
Alugupalli, Alugupalli, Ansel, Avrech, Barber, Baumgarth, Baumgarth, Baumgarth, Baumgarth, Ben-Hur, Berland, Boes, Boes, Briles, Cazac, Chace, Chen, Choi, Choi, Cole, Colombo, Cosenza, Cunningham, Dexter, Duber, Ehrenstein, Elvington, Flajnik, Forster, Fung, Gil-Cruz, Godin, Gordon, Ha, Haas, Hardy, Hardy, Hayakawa, Hayakawa, Holodick, Holodick, Holodick, Hooijkaas, Kantor, Kantor, Kawahara, Kearney, Kin, Kobayashi, Kretschmer, Kroese, Kroese, Lalor, Lalor, Lalor, Mercolino, Montecino-Rodriguez, Montecino-Rodriguez, Moon, Morris, Murakami, Nguyen, Nisitani, Ohdan, Okabe, Ouchida, Patel, Perdiguero, Rahyab, Reynolds, Sigal, Stoermann, Tominaga, Tornberg, van der Pol, Vas, Vaux, Waffarn, Wardemann, Watanabe, Yang, Yang, Yoshida, Yoshimoto, Yuan, Zhou   +85 more
core   +2 more sources

Cell surface antigens of human renal cancer defined by autologous typing

Journal of Experimental Medicine, 1979
Sera from 28 patients with renal cancer were tested for reactivity with surface antigens of cultured autologous renal cancer cells. Four serological assays were used to survey sera for autologous antibody.
R. Ueda, H. Shiku, M. Pfreundschuh, T. Takahashi, L. T. Li, W. Whitmore, H. Oettgen, L. Old   +7 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]

, 2018
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B., Katz, Steven C., Khalili, Marian, Morano, William F., Richard, Scott D., Thadi, Anusha   +5 more
core   +2 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Dissecting the Gene Expression, Localization, Membrane Topology, and Function of the Plasmodium falciparum STEVOR Protein Family

mBio, 2019
During its intraerythrocytic development, the malaria parasite Plasmodium falciparum exposes variant surface antigens (VSAs) on infected erythrocytes to establish and maintain an infection.
J. Stephan Wichers, Judith A. M. Scholz, Jan Strauss, Susanne Witt, Andrés Lill, Laura-Isabell Ehnold, Niklas Neupert, Benjamin Liffner, Renke Lühken, Michaela Petter, Stephan Lorenzen, Danny W. Wilson, Christian Löw, Catherine Lavazec, Iris Bruchhaus, Egbert Tannich, Tim W. Gilberger, Anna Bachmann   +17 more
doaj   +1 more source

Monoclonal Antibodies to Human Cell Surface Antigens

Current Protocols in Immunology, 2003
AbstractThis appendix lists the cluster of differentiation (CD) designations for the nearly 300 different leukocyte surface molecules that have been assigned and approved by the nomenclature committee of the International Union of Immunological societies (IUIS).
Hannes, Stockinger, Otto, Majdic, Walter, Knapp, Bernadette, Swart, Ian, Nicholson, Heddy, Zola   +5 more
openaire   +3 more sources