Results 211 to 220 of about 3,396,679 (311)

The dark side of the light (UVA): melanoma microenvironment and cell survival strategies. [PDF]

Cell Death Discov
Basu A, Thorsten P, Schumacher B, Kletsas D, Scharffetter-Kochanek K.   +4 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. [PDF]

Nat Commun
Shanmugam V, Tokcan N, Chafamo D, Sullivan S, Borji M, Martin H, Newton G, Nadaf N, Hanbury S, Barrera I, Cable D, Weir J, Ashenberg O, Pinkus G, Rodig S, Uhler C, Macosko E, Shipp M, Louissaint A, Chen F, Golub TR.   +20 more
europepmc   +1 more source

P1.08-060 Survival of Patients with Unsuspected N2 (Stage IIIA) Non-Small Cell Lung Cancer [PDF]

, 2017
Takashi Yamamichi, Masahiko Harada, Tsunekazu Hishima, Ayaka Asakawa, Masayuki Okui, Hirotoshi Horio   +5 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Critical Role of RPS4X in Modulating SCF Complex Formation and Cell Survival. [PDF]

Biomolecules
Ryu S, Kim MJ, Bando S, Tanaka Y, Mukai R, Ishihara Y, Tominaga T, Ohshima T.   +7 more
europepmc   +1 more source

RARE-56. RECURRENCE PATTERN AND SURVIVAL FOR RELAPSED INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMORS: A SINGLE-INSTITUTION EXPERIENCE [PDF]

, 2019
Lei Wen, Zhaoming Zhou, Juan Li, Cheng Zhou, Mingyao Lai, Linbo Cai   +5 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hijacking the unfolded protein response (UPR) pathway: Balancing viral infection and host cell survival. [PDF]

J Biol Chem
Chen H, Liu D, Hua J, Wu M, Hua Y, Feng C, He Z, Moffett P, Zhang K.   +8 more
europepmc   +1 more source

370. Enhanced Cell Survival, Differentiation and Down-Regulation of Hypoxia-Related Genes by Increased Oxygen Supply [PDF]

, 2011

openalex   +1 more source