Results 221 to 230 of about 3,396,679 (311)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging. [PDF]

Diabetes
Park J, Lokuge SD, Huang M, Wang S, Liu S, Liang J, Katturajan R, Marakovits C, Yang Z, Wan J, Dong XC.   +10 more
europepmc   +1 more source

Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma

George Joun, Emma G. Kempe, Brianna Chen, Jayden Sterling, Ramzi H. Abbassi, Willem Daniel du Preez, Ariadna Recasens, Teleri Clark, Tian Y. Du, Jason K. K. Low, Hani Kim, Pengyi Yang, Jasmine Khor, Monira Hoque, Dinesh C Idurthi, Mani Kuchibhotla, Ranjith Palanisamy, William T. Jorgensen, Andrew P. Montgomery, Jennifer H.E. Baker, Sarah L. Higginbottom, Eva Tomaskovic‐Crook, Jeremy M. Crook, Lipin Loo, Bryan W. Day, G. Gregory Neely, Ernesto Guccione, Terrance G. Johns, Michael Kassiou, Anthony S. Don, Lenka Munoz   +30 more
openalex   +1 more source

Addition of rituximab is not associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma.

, 2015
Bo Jia, Yuankai Shi, Suyi Kang, Sheng Yang, Shaoxuan Hu, Ye‐Xiong Li, Mei Dong, Weihu Wang, Jianliang Yang, Liqiang Zhou, Peng Liu, Shengyu Zhou, Yan Qin, Lin Gui, Changgong Zhang, Hua Lin, Shanshan Chen, Lin Wang, Xiaohui He   +18 more
openalex   +2 more sources

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy [PDF]

, 2015
Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe   +13 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos. [PDF]

Elife
Sanchez-Vasquez E, Bronner ME, Zernicka-Goetz M.   +2 more
europepmc   +1 more source

Regulation of mast cell function and survival in health and disease

, 2016
Katarina Lyberg
openalex  

A0767 – Senescence-associated miRNA in clear cell renal cell carcinoma: Exploring the role of the tumor immune microenvironment and predicting survival through senescence-associated factors

Zhenchuan Song, Tao Liu, C.D. Wang, Jing‐dong Zhou, Jingjiang Qiu, Yihan Wang, Yu Gong, Kunmei Gong   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source