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Targeting aging cells improves survival

Science, 2021
Drugs that remove senescent cells cut coronavirus deaths in old ...
Lynne S, Cox, Janet M, Lord
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Spheroids and cell survival

Critical Reviews in Oncology/Hematology, 2000
In contrast to most traditional cell culture systems, spheroids represent a unique opportunity to recapitulate aspects of cell homeostasis and as such better reflect in vivo tumor biology. This review highlights recent spheroid-based studies which have defined a role for intercellular adhesion in dictating cellular fate.
R C, Bates, N S, Edwards, J D, Yates
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Clonogenic Cell Survival Assay

2005
The clonogenic cell survival assay determines the ability of a cell to proliferate indefinitely, thereby retaining its reproductive ability to form a large colony or a clone. This cell is then said to be clonogenic. A cell survival curve is therefore defined as a relationship between the dose of the agent used to produce an insult and the fraction of ...
Anupama, Munshi   +2 more
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NSD and cell survival

The British Journal of Radiology, 1980
Lokajiceek et al. (1979) have recently proposed an equation relating cell survival to TDF. Since TDF is additive, their equation (3) is The fraction of cells surviving after a course of irradiation is taken as or However, their conclusion that where α is a constant, is only true for the special case where the proportion of cell recovery between ...
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CD4+ memory T cell survival

Current Opinion in Immunology, 2011
Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Survival of cells in anoxia

The British Journal of Radiology, 1968
Recent polemics concerned with the problem whether the oxygen effect is pertinent or irrelevant to clinical radiotherapy (Hall 1967; Alper 1968) raised, among others, the question: For how long a period do cells actually survive under the severely anoxic conditions which may prevail at some sites in a tumour?
B, Littbrand, L, Révész
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Plasma cell differentiation and survival

Current Opinion in Immunology, 2008
Humoral immunity depends on the regulated production and maintenance of antibody secreting cells during the course of an immune response. Recent insights into the transcriptional regulation of the initiation of plasma cell differentiation have clarified aspects of this process, particularly with respect to the choice between the memory B cell and ...
David, Tarlinton   +3 more
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Cytokine-Mediated Cell Survival

International Journal of Hematology, 2004
Pathways through which signals emanating from cytokine receptors support cell survival have long been a focus of intensive research. For Baf-3, a murine interleukin 3-dependent cell line, the 2 distinct pathways involved are JAK/STATs/Bcl-xL and Ras/PI3-K.
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Tumor Cell Survival

2002
The development of assays for measuring the survival of individual tumor cells revolutionized the study of experimental cancer therapy by enabling researchers to move from assessing the gross responses of tumors to measuring the survival of cells in the critical, clonogenic tumor-cell populations (1).
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Preconditioning and Stem Cell Survival

Journal of Cardiovascular Translational Research, 2009
The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium, infiltrated by the inflammatory and immune cells, offers a significant challenge to the transplanted donor stem cells. Massive cell death occurs during transplantation as well as following engraftment which significantly lowers the effectiveness of the heart cell therapy.
Husnain Kh, Haider, Muhammad, Ashraf
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