Results 1 to 10 of about 1,959,826 (221)

Cell therapies in the clinic [PDF]

Bioengineering & Translational Medicine, 2021
AbstractCell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics.
Mairead K. Heavey, Zongmin Zhao, Zongmin Zhao, Lily Li-Wen Wang, Lily Li-Wen Wang, Lily Li-Wen Wang, Morgan E. Janes, Morgan E. Janes, Morgan E. Janes, Aaron C. Anselmo, John R. Clegg, John R. Clegg, Supriya Prakash, Supriya Prakash, Ninad Kumbhojkar, Ninad Kumbhojkar, Samir Mitragotri, Samir Mitragotri, Neha Kapate, Neha Kapate, Neha Kapate   +20 more
openaire   +4 more sources

Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group

Asian Pacific Journal of Cancer Biology, 2023
Introduction: Myelodysplastic syndromes (MDS) are a group of haematological disorders, whose diagnosis is based mainly on cytological studies of blood and marrow cells and cytogenetic analysis.
Mohamed Amine Bekadja, Pierre Fenaux, Sabrina Akrouf, Redhouane Ahmed-Nacer, Rose-marie Hamladji, Amina Bouchakour, Souad Taoussi, Mohand Tahar Abad, Mohamed Bradai, Brahim Benzineb, Naima Mesli, M Cheritti, Z Zouaoui, Mohamed Benlazar, Soraya Bougherira, Fatiha Grifi, Hocine Ait-Ali, Malika allouda, Malika Djillali, Khadija Djouadi, Fatima Kherbache, Selma Hamdi, Hakim Hamouda, Imene Boumeida, Meriem Belhani, Nadia Boudjerra, Fatima Zohra Kaci, Soufi Osmani, Nabil Yafour, Soumia Barkat, Fatma Soltani, Razika Nacib, Mahdia Saidi, Laid Touati, Noureddine Lakhdari, Samira Zouani, Hadj Touhami, Djamel Saidi, Lamia Cherif Louazani, Mohamed Ramaoun, Cherifa Akkal, Nemra Mehalhal, Amina Krim, Noureddine Sidimansour, Zohra Ouchenane, Nadia Zidani, Salim Nekkal, Samia Barkat, Y Ouarlent, Mohamed Aberkane, Salah Eddine Belakehal, Aissa Bachiri, Samir Baghdad   +52 more
doaj   +1 more source

Cell therapy for cystinosis [PDF]

Nephrology Dialysis Transplantation, 2010
In the September 2009 issue of Blood, Syres et al. [1] report on syngeneic bone marrow cell (BMC) and haematopoietic stem cell (HSC) therapy as a successful treatment in a mouse model of cystinosis, an autosomal recessive metabolic disease caused by a defect in the transport of cystine across the lysosomal membrane. The accumulation of cystine crystals
Corinne Antignac, Corinne Antignac, Olivier Devuyst, Sara Terryn   +3 more
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Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats

Stem Cells International, 2022
Neural stem cells (NSCs) and derivatives are potential cellular sources to treat neurological diseases. In the current study, we reprogrammed human peripheral blood mononuclear cells into induced NSCs (iNSCs) and inserted GFP gene into the AAVS1 site for
Mengjia Li, Zhengbo Wang, Tianqi Zheng, Tianzhuang Huang, Baoguo Liu, Deqiang Han, Sumei Liu, Bochao Liu, Mo Li, Wei Si, Y. Alex Zhang, Yuyu Niu, Zhiguo Chen   +12 more
doaj   +1 more source

Cell sheets in cell therapies [PDF]

Cytotherapy, 2018
This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing ...
Jason D. Whittle, Louise E. Smith, Giles T. S. Kirby, Robert D. Short, Robert D. Short, Andrew Michelmore   +5 more
openaire   +5 more sources

Enhanced therapeutic effects of mesenchymal stem cell-derived extracellular vesicles within chitosan hydrogel in the treatment of diabetic foot ulcers

Journal of Materials Science: Materials in Medicine, 2023
Extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising candidates for cell-free therapy in various diseases, including chronic cutaneous wounds.
Shuangshuang Yang, Siyu Chen, Chengpeng Zhang, Jing Han, Chunyuan Lin, Xiaohui Zhao, Huizhen Guo, Yi Tan   +7 more
doaj   +1 more source

Cell therapy of burns [PDF]

Cell Proliferation, 2011
AbstractSevere burns remain a life‐threatening local and general inflammatory condition often with serious sequelae, despite remarkable progress in their treatment over the past three decades. Cultured epidermal autografts, the first and still most up‐to‐date cell therapy for burns, plays a key role in that progress, but drawbacks to this need to be ...
Leclerc, T., Thepenier, C., Jault, P., Bey, E., Peltzer, J., Trouillas, M., Duhamel, P., Bargues, L., Prat, Marc, Bonderriter, M., Lataillade, Jean-Jacques   +10 more
openaire   +4 more sources

CAR-T Cell Therapy [PDF]

International Journal of Molecular Sciences, 2020
CAR-T therapy has revolutionized the treatment of select hematological malignancies, namely, acute lymphoblastic leukemia and large B-cell lymphomas [...]
openaire   +8 more sources

Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]

npj Systems Biology and Applications, 10(1), 105 (2024), 2023
As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv   +1 more source

The 3Rs of Cell Therapy [PDF]

Stem Cells Translational Medicine, 2016
Abstract The 3Rs for a good education are “reading, 'riting, and 'rithmetic.” The basis for good health care solutions for the emergent field of cell therapy in the future will also involve 3Rs: regulation, reimbursement, and realization of value. The business models in this new field of cell therapy will involve these 3Rs.
Caplan, AI, Mason, C, Reeve, B
openaire   +4 more sources