Results 1 to 10 of about 17,214,210 (344)

CAR-T cell therapy: current limitations and potential strategies

Blood Cancer Journal, 2021
Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit ...
Robert C. Sterner, Rosalie M. Sterner
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Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group

Asian Pacific Journal of Cancer Biology, 2023
Introduction: Myelodysplastic syndromes (MDS) are a group of haematological disorders, whose diagnosis is based mainly on cytological studies of blood and marrow cells and cytogenetic analysis.
Mohamed Amine Bekadja, Pierre Fenaux, Sabrina Akrouf, Redhouane Ahmed-Nacer, Rose-marie Hamladji, Amina Bouchakour, Souad Taoussi, Mohand Tahar Abad, Mohamed Bradai, Brahim Benzineb, Naima Mesli, M Cheritti, Z Zouaoui, Mohamed Benlazar, Soraya Bougherira, Fatiha Grifi, Hocine Ait-Ali, Malika allouda, Malika Djillali, Khadija Djouadi, Fatima Kherbache, Selma Hamdi, Hakim Hamouda, Imene Boumeida, Meriem Belhani, Nadia Boudjerra, Fatima Zohra Kaci, Soufi Osmani, Nabil Yafour, Soumia Barkat, Fatma Soltani, Razika Nacib, Mahdia Saidi, Laid Touati, Noureddine Lakhdari, Samira Zouani, Hadj Touhami, Djamel Saidi, Lamia Cherif Louazani, Mohamed Ramaoun, Cherifa Akkal, Nemra Mehalhal, Amina Krim, Noureddine Sidimansour, Zohra Ouchenane, Nadia Zidani, Salim Nekkal, Samia Barkat, Y Ouarlent, Mohamed Aberkane, Salah Eddine Belakehal, Aissa Bachiri, Samir Baghdad   +52 more
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CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

Molecular Cancer, 2023
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This approach consists of genetically engineered immune cells expressing a surface receptor, called CAR, that ...
Karama Makni Maalej, M. Merhi, V. Inchakalody, S. Mestiri, M. Alam, C. Maccalli, H. Cherif, Shahab Uddin, M. Steinhoff, F. Marincola, S. Dermime   +10 more
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From bench to bedside: the history and progress of CAR T cell therapy

Frontiers in Immunology, 2023
Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in cancer care since the approval of tisagenlecleucel by the Food and Drug Administration in 2017 for the treatment of pediatric and young adult patients with relapsed or ...
Aroshi Mitra, Amrita Barua, Lu-ping Huang, S. Ganguly, Qin Feng, Bin He   +5 more
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Long-term outcomes following CAR T cell therapy: what we know so far

Nature Reviews Clinical Oncology, 2023
Chimeric antigen receptors (CAR) are engineered fusion proteins designed to target T cells to antigens expressed on cancer cells. CAR T cells are now an established treatment for patients with relapsed and/or refractory B cell lymphomas, B cell acute ...
Kathryn M. Cappell, J. Kochenderfer
semanticscholar   +1 more source

Challenges and new technologies in adoptive cell therapy

Journal of Hematology & Oncology, 2023
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and chimeric antigen receptor (CAR)-T cell therapies, many novel strategies ...
Pengchao Zhang, Guizhong Zhang, X. Wan
semanticscholar   +1 more source

The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy

Stem cell research & therapeutics, 2023
With the continuous improvement of human technology, the medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell therapy has successfully created a research boom in the modern medical ...
Jingxuan Li, Zewen Wu, Li Zhao, Yang Liu, Yazhen Su, Xueyan Gong, Fancheng Liu, Liyun Zhang   +7 more
semanticscholar   +1 more source

Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats

Stem Cells International, 2022
Neural stem cells (NSCs) and derivatives are potential cellular sources to treat neurological diseases. In the current study, we reprogrammed human peripheral blood mononuclear cells into induced NSCs (iNSCs) and inserted GFP gene into the AAVS1 site for
Mengjia Li, Zhengbo Wang, Tianqi Zheng, Tianzhuang Huang, Baoguo Liu, Deqiang Han, Sumei Liu, Bochao Liu, Mo Li, Wei Si, Y. Alex Zhang, Yuyu Niu, Zhiguo Chen   +12 more
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CAR-T cell therapy in multiple myeloma: Current limitations and potential strategies

Frontiers in Immunology, 2023
Over the last decade, the survival outcome of patients with multiple myeloma (MM) has been substantially improved with the emergence of novel therapeutic agents, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies ...
Xiaoming Zhang, Hui Zhang, H. Lan, Jinming Wu, Yang Xiao   +4 more
semanticscholar   +1 more source

Enhanced therapeutic effects of mesenchymal stem cell-derived extracellular vesicles within chitosan hydrogel in the treatment of diabetic foot ulcers

Journal of Materials Science: Materials in Medicine, 2023
Extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising candidates for cell-free therapy in various diseases, including chronic cutaneous wounds.
Shuangshuang Yang, Siyu Chen, Chengpeng Zhang, Jing Han, Chunyuan Lin, Xiaohui Zhao, Huizhen Guo, Yi Tan   +7 more
doaj   +1 more source