Results 11 to 20 of about 3,286,390 (370)

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells toward a phagocytic and anti ...
Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa, Eleuterio Lombardo   +10 more
doaj   +1 more source

Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Scientific Reports, 2023
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies.
Nadine von Auw, Robert Serfling, Reni Kitte, Nadja Hilger, Chengkang Zhang, Clara Gebhardt, Anna Duenkel, Paul Franz, Ulrike Koehl, Stephan Fricke, U. Sandy Tretbar   +10 more
doaj   +1 more source

The Pharmacology of T Cell Therapies [PDF]

Molecular Therapy - Methods & Clinical Development, 2018
Adoptive cellular therapy using T cells with tumor specificity derived from either natural T cell receptors (TCRs) or an artificial chimeric antigen receptor (CAR) has reached late phase clinical testing, with two CAR T cell therapies achieving regulatory approval within the United States in 2017.
Vijay Bhoj, Michael C. Milone
openaire   +4 more sources

Cell and Cell Free Therapies in Osteoarthritis

Biomedicines, 2021
Osteoarthritis (OA) is the most common articular disease in adults and has a current prevalence of 12% in the population over 65 years old. This chronic disease causes damage to articular cartilage and synovial joints, causing pain and leading to a negative impact on patients’ function, decreasing quality of life.
Joaquin Sopena, Joaquin Sopena, Deborah Chicharro, Deborah Chicharro, José M. Carrillo, José M. Carrillo, Marta Torres-Torrillas, Marta Torres-Torrillas, Mónica Rubio, Mónica Rubio, Pau Peláez, Pau Peláez, Elena Damiá, Elena Damiá, Ayla Del Romero, Ayla Del Romero, Belén Cuervo, Belén Cuervo, Laura Miguel, Laura Miguel   +19 more
openaire   +5 more sources

Phosphate restriction using a processed clay mineral reduces vascular pathologies and microalbuminuria in rats with chronic renal failure

BMC Nephrology, 2022
Background The progression of chronic kidney disease (CKD) is associated with an increasing risk of cardiovascular morbidity and mortality due to elevated serum phosphate levels.
Jacqueline Hofrichter, Kai Sempert, Claus Kerkhoff, Anne Breitrück, Reinhold Wasserkort, Steffen Mitzner   +5 more
doaj   +1 more source

The effect of platelet lysate in culture of PDLSCs: an in vitro comparative study [PDF]

PeerJ, 2019
Background Cellular therapy clinical applications require large-scale production of stem cells. Therefore, abundance, ease of isolation, and proliferative potential are the most important factors in choosing the appropriate source of cells for ...
Duaa A. Abuarqoub, Nazneen Aslam, Raghda B. Barham, Nidaa A. Ababneh, Diana A. Shahin, Abdallah A. Al-oweidi, Hanan D. Jafar, Mazin A. Al-Salihi, Abdalla S. Awidi   +8 more
doaj   +2 more sources

Cell therapy for stroke [PDF]

Neurotherapeutics, 2004
Increasing experimental evidence suggests that cell transplantation can enhance recovery from stroke in animal models of focal cerebral ischemia. Clinical trials have been investigating the effects of a human immortalized neuronal cell line and porcine fetal neurons in stroke victims with persistent and stable deficits. Preclinical studies are focusing
Louis R. Caplan, Daniel M. Rosenbaum, Jonathan Dinsmore, Sean I Savitz, Lawrence R. Wechsler   +4 more
openaire   +3 more sources

DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma

Human Vaccines & Immunotherapeutics, 2021
Introduction To deliver specific antigens in tumor immunotherapy, tumor cell lysates are commonly used to sensitize dendritic cells (DCs). However, the lysates possess low immunogenicity and contain many types of non-tumor-related antigens, which may ...
Heran Ma, Yi Tan, Dingke Wen, Na Qu, Qunfang Kong, Kun Li, Suxia Ma, Jianhui Zhang   +7 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Differences and similarities between cancer and somatic stem cells: therapeutic implications

Stem Cell Research & Therapy, 2020
Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments.
Fiorella Rossi, Hunter Noren, Richard Jove, Vladimir Beljanski, Karl-Henrik Grinnemo   +4 more
doaj   +1 more source