Results 11 to 20 of about 17,214,210 (344)

A new era of macrophage-based cell therapy

Experimental and Molecular Medicine, 2023
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective ...
Y. Na, Sang Wha Kim, S. Seok
semanticscholar   +1 more source

Biomaterials for in situ cell therapy

BMEmat, 2023
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo cell engineering, which requires sophisticated manufacturing processes ...
Chang Wang, Siyu Wang, Diana D. Kang, Yizhou Dong   +3 more
semanticscholar   +1 more source

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells toward a phagocytic and anti ...
Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa, Eleuterio Lombardo   +10 more
doaj   +1 more source

Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Scientific Reports, 2023
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies.
Nadine von Auw, Robert Serfling, Reni Kitte, Nadja Hilger, Chengkang Zhang, Clara Gebhardt, Anna Duenkel, Paul Franz, Ulrike Koehl, Stephan Fricke, U. Sandy Tretbar   +10 more
doaj   +1 more source

CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges

Frontiers in Immunology, 2022
Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer treatment, and it has achieved unprecedented success in hematological malignancies, especially in relapsed/refractory (R/R) B cell malignancies.
Xiaomin Zhang, Lingling Zhu, Hui Zhang, Shanshan Chen, Yang Xiao   +4 more
semanticscholar   +1 more source

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma.

New England Journal of Medicine, 2020
BACKGROUND Patients with relapsed or refractory mantle-cell lymphoma who have disease progression during or after the receipt of Bruton's tyrosine kinase (BTK) inhibitor therapy have a poor prognosis. KTE-X19, an anti-CD19 chimeric antigen receptor (CAR)
Michael L. Wang, J. Muñoz, A. Goy, F. Locke, C. Jacobson, B. Hill, J. Timmerman, H. Holmes, S. Jaglowski, I. Flinn, P. Mcsweeney, D. Miklos, J. Pagel, M. Kersten, N. Milpied, H. Fung, M. Topp, R. Houot, A. Beitinjaneh, W. Peng, Lianqing Zheng, J. Rossi, R. Jain, A. Rao, P. Reagan   +24 more
semanticscholar   +1 more source

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Nature, 2022
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system1.
R. Majzner, S. Ramakrishna, K. Yeom, Shabnum Patel, Harshini Chinnasamy, Liora M. Schultz, R. Richards, Li Jiang, Valentin V. Barsan, Rebecca Mancusi, Anna C. Geraghty, Zinaida Good, A. Mochizuki, Shawn M. Gillespie, A. Toland, Jasia Mahdi, Agnes Reschke, Esther H Nie, Isabelle Chau, M. Rotiroti, Christopher W. Mount, C. Baggott, S. Mavroukakis, Emily Egeler, J. Moon, C. Erickson, Sean Green, Michael Kunicki, M. Fujimoto, Zachary J Ehlinger, Warren D. Reynolds, Sreevidya Kurra, K. Warren, Snehit Prabhu, H. Vogel, L. Rasmussen, Timothy T. Cornell, S. Partap, Paul G. Fisher, C. Campen, Mariella G. Filbin, G. Grant, Bita Sahaf, K. Davis, S. Feldman, C. Mackall, Michelle Monje   +46 more
semanticscholar   +1 more source

Phosphate restriction using a processed clay mineral reduces vascular pathologies and microalbuminuria in rats with chronic renal failure

BMC Nephrology, 2022
Background The progression of chronic kidney disease (CKD) is associated with an increasing risk of cardiovascular morbidity and mortality due to elevated serum phosphate levels.
Jacqueline Hofrichter, Kai Sempert, Claus Kerkhoff, Anne Breitrück, Reinhold Wasserkort, Steffen Mitzner   +5 more
doaj   +1 more source

DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma

Human Vaccines & Immunotherapeutics, 2021
Introduction To deliver specific antigens in tumor immunotherapy, tumor cell lysates are commonly used to sensitize dendritic cells (DCs). However, the lysates possess low immunogenicity and contain many types of non-tumor-related antigens, which may ...
Heran Ma, Yi Tan, Dingke Wen, Na Qu, Qunfang Kong, Kun Li, Suxia Ma, Jianhui Zhang   +7 more
doaj   +1 more source

The effect of platelet lysate in culture of PDLSCs: an in vitro comparative study [PDF]

PeerJ, 2019
Background Cellular therapy clinical applications require large-scale production of stem cells. Therefore, abundance, ease of isolation, and proliferative potential are the most important factors in choosing the appropriate source of cells for ...
Duaa A. Abuarqoub, Nazneen Aslam, Raghda B. Barham, Nidaa A. Ababneh, Diana A. Shahin, Abdallah A. Al-oweidi, Hanan D. Jafar, Mazin A. Al-Salihi, Abdalla S. Awidi   +8 more
doaj   +2 more sources