Results 21 to 30 of about 2,050,369 (162)

Fetal Tissues Tested for Microbial Sterility by Culture- and PCR-Based Methods Can be Safely Used in Clinics

Cell Transplantation, 2017
Cell preparations to be used in clinical practice must be free of infectious agents. Safety concerns are especially elevated upon the use of human fetal tissues, which are otherwise highly advantageous in cell therapy.
Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina, Alla Duda, Mariya Klunnyk, Khrystyna Sorochynska   +5 more
doaj   +1 more source

Identification of very early inflammatory markers in a porcine myocardial infarction model

BMC Veterinary Research, 2019
Background Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatments, which are fundamental to ...
Esther López, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Rebeca Blázquez, Federica Marinaro, Ana Abad, Helena Martín, Claudia Báez, Virginia Blanco, Verónica Crisóstomo, Javier García Casado   +10 more
doaj   +1 more source

Potential and challenges of specifically isolating extracellular vesicles from heterogeneous populations

Scientific Reports, 2021
Extracellular vesicles (EVs) have attracted interest due to their ability to provide diagnostic information from liquid biopsies. Cells constantly release vesicles divers in size, content and features depending on the biogenesis, origin and function ...
Susann Allelein, Paula Medina-Perez, Ana Leonor Heitor Lopes, Sabrina Rau, Gerd Hause, Andreas Kölsch, Dirk Kuhlmeier   +6 more
doaj   +1 more source

Three doses of a recombinant conjugated SARS-CoV-2 vaccine early after allogeneic hematopoietic stem cell transplantation: predicting indicators of a high serologic response—a prospective, single-arm study

Frontiers in Immunology, 2023
BackgroundAllogeneic hematopoietic stem cell transplant (allo-HSCT) recipients must be vaccinated against SARS-CoV-2 as quickly as possible after transplantation.
Maryam Barkhordar, Bahram Chahardouli, Alireza Biglari, Mohammad Ahmadvand, Tanaz Bahri, Farshid Alaeddini, Leyla Sharifi Aliabadi, Seied Saeid Noorani, Fahimeh Bagheri Amiri, Mohammad Biglari, Mohammad Reza Shemshadi, Ardeshir Ghavamzadeh, Mohammad Vaezi   +12 more
doaj   +1 more source

Cell Therapy [PDF]

Journal of the American Society of Nephrology, 2003
Cell therapy is one of the most exciting fields in translational medicine. It stands at the intersection of a variety of rapidly developing scientific disciplines: stem cell biology, immunology, tissue engineering, molecular biology, biomaterials, transplantation biology, regenerative medicine, and clinical research. Cell-based therapy may develop into
openaire   +1 more source

Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity

Journal of Immunology Research, 2023
Objective. The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) has recently gained attention. Costimulatory molecules are membrane proteins strictly associated with T-cell receptor (TCR), acting by activating or inhibiting T ...
Fulvia Ceccarelli, Francesco Natalucci, Alessandra Di Filippo, Giulio Olivieri, Chiara Napoletano, Aurelia Rughetti, Marianna Nuti, Ilaria Grazia Zizzari, Fabrizio Conti   +8 more
doaj   +1 more source

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Molecular Cancer, 2023
Background Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors.
Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman   +16 more
doaj   +1 more source

Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Frontiers in Medicine, 2022
Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding.
Reetta A. E. Eriksson, Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Seppo Ylä-Herttuala, Kari J. Airenne   +16 more
doaj   +1 more source

Arterial hypertension aggravates innate immune responses after experimental stroke

Frontiers in Cellular Neuroscience, 2015
Arterial hypertension is not only the leading risk factor for stroke, but also attribute to impaired recovery and poor outcome. The latter could be explained by hypertensive vascular remodeling that aggravates perfusion deficits and blood brain barrier ...
Karoline eMöller, Karoline eMöller, Claudia ePösel, Alexander eKranz, Isabell eSchulz, Johanna eScheibe, Nadine eDidwischus, Nadine eDidwischus, Johannes eBoltze, Johannes eBoltze, Gesa eWeise, Gesa eWeise, Daniel-Christoph eWagner   +12 more
doaj   +1 more source

Characterization of human induced pluripotent stems cells: Current approaches, challenges, and future solutions

Biotechnology Reports, 2023
Human induced pluripotent stem cells (iPSC) have demonstrated massive potentials for use in regenerative and personalized medicine due to their ability to expand in culture and differentiate into specialized cells with therapeutic benefits.
Sahana Suresh Babu, Haritha Duvvuru, Jillian Baker, Stephanie Switalski, Mehdi Shafa, Krishna Morgan Panchalingam, Saedeh Dadgar, Justin Beller, Behnam Ahmadian Baghbaderani   +8 more
doaj   +1 more source