Results 31 to 40 of about 3,606,010 (253)
Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: Implications for muscle regeneration and repair [PDF]
, 2011 Background: Despite the initial promise of myoblast transfer therapy to restore dystrophin in Duchenne muscular dystrophy patients, clinical efficacy has been limited, primarily by poor cell survival post-transplantation. Murine muscle derived stem cells
Bucsek, MJ +4 more
core +8 more sources
Frontiers in Immunology, 2022 Nonviral transposon piggyBac (PB) and lentiviral (LV) vectors have been used to deliver chimeric antigen receptor (CAR) to T cells. To understand the differences in the effects of PB and LV on CAR T-cell functions, a CAR targeting CD19 was cloned into PB
Zhicai Lin +17 more
doaj +1 more source
Stem Cell Imaging: Tools to Improve Cell Delivery and Viability. [PDF]
, 2016 Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and
Jokerst, Jesse V, Wang, Junxin
core +3 more sources
Potential solutions for manufacture of CAR T cells in cancer immunotherapy
Nature Communications, 2022 CAR T cell therapy is an effective cancer treatment, but biological and manufacturing hurdles hamper its broad breakthrough. Although the first step towards automated manufacture of CAR cells has been taken, new technologies are needed to enable the ...
Ulrich Blache +4 more
doaj +1 more source
Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]
, 2018 Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P +10 more
core +1 more source
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]
, 2017 Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E +11 more
core +1 more source
Cell Transplantation, 2017 Cell preparations to be used in clinical practice must be free of infectious agents. Safety concerns are especially elevated upon the use of human fetal tissues, which are otherwise highly advantageous in cell therapy.
Yakov Vitrenko +5 more
doaj +1 more source
Identification of very early inflammatory markers in a porcine myocardial infarction model
BMC Veterinary Research, 2019 Background Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatments, which are fundamental to ...
Esther López +10 more
doaj +1 more source
Scientific Reports, 2021 Extracellular vesicles (EVs) have attracted interest due to their ability to provide diagnostic information from liquid biopsies. Cells constantly release vesicles divers in size, content and features depending on the biogenesis, origin and function ...
Susann Allelein +6 more
doaj +1 more source