Results 11 to 20 of about 521,452 (268)

IRF4 expression is low in Philadelphia negative myeloproliferative neoplasms and is associated with a worse prognosis

Experimental Hematology & Oncology, 2021
Interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various hematologic malignancies. Its expression has been related to the negative regulation of myeloid-derived suppressor cells (MDSCs) and the polarization of anti-inflammatory M2
Cosimo Cumbo, Francesco Tarantini, Luisa Anelli, Antonella Zagaria, Immacolata Redavid, Crescenzio Francesco Minervini, Nicoletta Coccaro, Giuseppina Tota, Alessandra Ricco, Elisa Parciante, Maria Rosa Conserva, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +13 more
doaj   +1 more source

Cell transplantation for diabetes [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
For 30 years there has been experimental work aimed at transplanting islets for the treatment of diabetes with a view to curing the disease and preventing the secondary complications. Many technical difficulties were experienced, first in isolating the islets without damaging them, and second in finding a suitable place to inject them, but until ...
openaire   +2 more sources

Patient risk stratification and tailored clinical management of post‐transplant CMV‐, EBV‐, and BKV‐infections by monitoring virus‐specific T‐cell immunity

eJHaem, 2021
Background Despite routine post‐transplant viral monitoring and pre‐emptive therapy, viral infections remain a major cause of allogeneic hematopoietic cell transplantation‐related morbidity and mortality.
Anastasia Papadopoulou, Kiriakos Koukoulias, Maria Alvanou, Vassilios K. Papadopoulos, Zoe Bousiou, Vasiliki Kalaitzidou, Fotini S. Kika, Apostolia Papalexandri, Despina Mallouri, Ioannis Batsis, Ioanna Sakellari, Achilles Anagnostopoulos, Evangelia Yannaki   +12 more
doaj   +1 more source

Functional SARS-CoV-2-specific T cells of donor origin in allogeneic stem cell transplant recipients of a T-cell-replete infusion: A prospective observational study

Frontiers in Immunology, 2023
In the current post-pandemic era, recipients of an allogeneic hematopoietic stem cell transplant (HCT) deserve special attention. In these vulnerable patients, vaccine effectiveness is reduced by post-transplant immune-suppressive therapy; consequently ...
Corinna La Rosa, Flavia Chiuppesi, Yoonsuh Park, Qiao Zhou, Dongyun Yang, Ketevan Gendzekhadze, Minh Ly, Jing Li, Teodora Kaltcheva, Sandra Ortega Francisco, Miguel-Angel Gutierrez, Haris Ali, Salman Otoukesh, Idoroenyi Amanam, Amandeep Salhotra, Vinod A. Pullarkat, Ibrahim Aldoss, Michael Rosenzweig, Ahmed M. Aribi, Anthony S. Stein, Guido Marcucci, Sanjeet Singh Dadwal, Ryotaro Nakamura, Stephen J. Forman, Monzr M. Al Malki, Don J. Diamond   +25 more
doaj   +1 more source

Robust SARS-COV-2-specific T-cell immune memory persists long-term in immunocompetent individuals post BNT162b2 double shot

Heliyon, 2022
Background: A robust efficiency of mRNA vaccines against coronavirus disease-2019 has been demonstrated, however, the intended long-term protection against SARS-CoV-2 has been challenged by the waning humoral and cellular immunity over time, leading to a
Anastasia Papadopoulou, Fani Stavridou, Maria Giannaki, Kiriaki Paschoudi, Fani Chatzopoulou, Eleni Gavriilaki, Grigorios Georgolopoulos, Achilles Anagnostopoulos, Evangelia Yannaki   +8 more
doaj   +1 more source

FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study

Turkish Journal of Hematology, 2018
Objective: This study aimed to evaluate DNMT3A exon 23 mutations and their prognostic impacts in the presence of NPM1 and FLT3 mutations in acute myeloid leukemia (AML) patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT ...
Majid Teremmahi Ardestani, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Mahdi Jalili, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +9 more
doaj   +1 more source

Donor Lymphocyte Infusion and Molecular Monitoring for Relapsed Myelofibrosis After Hematopoietic Cell Transplantation

HemaSphere, 2023
Hematopoietic cell transplantation (HCT) is a curative approach for myelofibrosis patients, but relapse is a major cause of treatment failure. We investigated the effect of donor lymphocyte infusion (DLI) in 37 patients with molecular (n = 17) or ...
Nico Gagelmann, Christine Wolschke, Anita Badbaran, Dietlinde Janson, Carolina Berger, Evgeny Klyuchnikov, Francis Ayuk, Boris Fehse, Nicolaus Kröger   +8 more
doaj   +1 more source

iPS cells for transplantation [PDF]

Current Opinion in Organ Transplantation, 2011
The induced pluripotent stem (iPS) cells from patient's somatic cells could be a useful source for drug discovery and cell transplantation therapies. However, there are still several problems to be solved in terms of safety concerns. We herein summarize the current knowledge about iPS cells and the obstacles that must be overcome before the cells can ...
openaire   +2 more sources

Clonal Hematopoiesis at the Crossroads of Inflammatory Bowel Diseases and Hematological Malignancies: A Biological Link?

Frontiers in Oncology, 2022
Inflammatory bowel diseases (IBDs) are a group of chronic conditions of the gastrointestinal tract in which nationwide studies have revealed a higher risk of hematological malignancies (HMs).
Cosimo Cumbo, Francesco Tarantini, Antonella Zagaria, Luisa Anelli, Crescenzio Francesco Minervini, Nicoletta Coccaro, Giuseppina Tota, Luciana Impera, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Paola Carluccio, Mario Delia, Annamaria Giordano, Maria Chiara Longo, Tommasina Perrone, Antonella Russo Rossi, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +19 more
doaj   +1 more source

Islet cell transplantation [PDF]

Postgraduate Medical Journal, 2007
Abstract People with type 1 diabetes have normal exocrine pancreatic function, making islet cell rather than whole organ transplantation an attractive option. Achieving insulin independence in type 1 diabetes was the perceived goal of islet cell transplantation.
Srinivasan, P, Huang, G C, Amiel, S A, Heaton, N D   +3 more
openaire   +3 more sources