Results 1 to 10 of about 11,200 (227)
Transplantation or islets of Langerhans: new developments
Swiss Medical Weekly, 2001 The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes.
A Caulfield +4 more
doaj +3 more sources
Strategies toward single-donor islets of Langerhans transplantation. [PDF]
Curr Opin Organ Transplant, 2011 The current review addresses a critical need in clinical islet transplantation, namely the routine transition from the requirement of two to four donors down to one donor per recipient. The ability to achieve single-donor islet transplantation will provide many more islet grafts for treatment of an ever-expanding patient base with type 1 diabetes (T1DM)
Shapiro AM.
europepmc +4 more sources
Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. [PDF]
PLoS ONE, 2013 Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction ...
Mijke Buitinga +8 more
doaj +7 more sources
A Practical Guide to Rodent Islet Isolation and Assessment [PDF]
Biological Procedures Online, 2009 Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process.
Carter Jeffrey +4 more
doaj +6 more sources
The pancreatic islet: a micro-organ in control [PDF]
CellR4, 2021 The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and islet dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and ...
M. Abdulreda, P. Berggren
doaj +1 more source
Protecting islet functional viability using mesenchymal stromal cells
Stem Cells Translational Medicine, 2021 Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes.
Ella L. Hubber +2 more
doaj +1 more source
Surface Coating of Islets of Langerhans by Activated Polyethylene Glycol [PDF]
علوم و تکنولوژی پلیمر, 2008 The final treatment for diabetes is transplantation of islets of Langerhans. One of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol.
S. Hashemi Najafabadi +3 more
doaj +1 more source
Transplantation technologies for treatment of carbohydrate metabolism disorders
Вестник трансплантологии и искусственных органов, 2020 The review includes results of retrospective and prospective clinical studies (foreign and national) and guidelines on the use of transplantation technologies for treatment of type 1 diabetes and pancreatogenic diabetes in chronic pancreatitis and ...
V. Е. Zagainov +4 more
doaj +1 more source
Arquivos de Gastroenterologia, 2000 A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB +3 more
doaj +1 more source
Islet isolation assessment in man and large animals [PDF]
, 1990 Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R +25 more
core +1 more source