Results 1 to 10 of about 165,997,933 (148)
Cell Transplantation, 2000 Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections.
Alessandra Rammcoli +7 more
doaj +5 more sources
Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices
Cell Transplantation, 1992 In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets.
Seh-Huang Chao +3 more
doaj +1 more source
Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions [PDF]
Endocrinology and Metabolism, 2017 Impaired awareness of hypoglycemia has been found to be prevalent in 20% to 40% of people with type 1 diabetes. If a similar prevalence exists in Koreans with type 1 diabetes, at a minimum, thousands of people with type 1 diabetes suffer at least one ...
Sang-Man Jin
doaj +1 more source
The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity
Frontiers in Endocrinology, 2021 The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone regulating glucose uptake and metabolism.
Erwin Ilegems +5 more
doaj +1 more source
Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives
Clinical Medicine Insights: Endocrinology and Diabetes, 2019 Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy.
Varun Pathak +4 more
doaj +1 more source
Journal of Diabetes Investigation, EarlyView.ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley +1 more source
Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat
Cell Transplantation, 1994 Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for ...
Andrew J. Portis +2 more
doaj +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, Volume 13, Issue 53, 24 September 2026.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Redox-Dependent Inflammation in Islet Transplantation Rejection
Frontiers in Endocrinology, 2018 Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans.
Jessie M. Barra, Hubert M. Tse
doaj +1 more source