Results 1 to 10 of about 6,194 (116)

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2010
Islet transplantation is a promising treatment for diabetes but long-term success is limited by progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) promote beta cell apoptosis and rapid amyloid formation occurs in transplanted islets.
Daniel Raleigh, J Oberholzer, S Bertera   +2 more
exaly   +3 more sources

Fresh Islets are more Effective for Islet Transplantation than Cultured Islets [PDF]

Cell Transplantation, 2012
For clinical islet transplantation, isolated islets deteriorate rapidly in culture, although culturing islets prior to transplantation provides flexibility for evaluation of isolated islets and pretreatment of patients. In the present study, we compared human fresh islets to cultured islets with in vitro and in vivo assays.
Hirofumi Noguchi M.D., Ph.D., Bashoo Naziruddin, Andrew Jackson, Masayuki Shimoda, Tetsuya Ikemoto, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Nicholas Onaca, Marlon F. Levy, Shinichi Matsumoto   +14 more
openaire   +3 more sources

Superiority of Small Islets in Human Islet Transplantation [PDF]

Diabetes, 2007
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior to large islets both in vitro and in vivo.
Lehmann, R, Zuellig, R A, Kugelmeier, P, Baenninger, P B, Moritz, W, Perren, A, Clavien, P A, Weber, M, Spinas, G A   +8 more
openaire   +5 more sources

Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis

BMC Medicine, 2022
Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent.
Ehsan Alvandi, Wilson K. M. Wong, Mugdha V. Joglekar, Kevin J. Spring, Anandwardhan A. Hardikar   +4 more
doaj   +1 more source

Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation

Frontiers in Endocrinology, 2023
Mitochondria are the powerhouse of the cell and dynamically control fundamental biological processes including cell reprogramming, pluripotency, and lineage specification.
Ila Tewari Jasra, Nerea Cuesta-Gomez, Kevin Verhoeff, Braulio A. Marfil-Garza, Braulio A. Marfil-Garza, Nidheesh Dadheech, A. M. James Shapiro   +6 more
doaj   +1 more source

Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes

Frontiers in Endocrinology, 2023
Cystic fibrosis (CF) is a multi-organ disease caused by loss-of-function mutations in CFTR (which encodes the CF transmembrane conductance regulator ion channel).
Sarah S. Malik, Sarah S. Malik, Diksha Padmanabhan, Diksha Padmanabhan, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle   +7 more
doaj   +1 more source

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Frontiers in Cell and Developmental Biology, 2022
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. Using
Federica Fantuzzi, Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop, Miriam Cnop   +19 more
doaj   +1 more source

Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells

Metabolites, 2021
Pancreatic β cells secrete the hormone insulin into the bloodstream and are critical in the control of blood glucose concentrations. β cells are clustered in the micro-organs of the islets of Langerhans, which have a rich capillary network.
Louise Cottle, Ian Gilroy, Kylie Deng, Thomas Loudovaris, Helen E. Thomas, Anthony J. Gill, Jaswinder S. Samra, Melkam A. Kebede, Jinman Kim, Peter Thorn   +9 more
doaj   +1 more source

Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death

Metabolites, 2023
A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely ...
Yi-Chun Chen, Andrew J. Lutkewitte, Halesha D. Basavarajappa, Patrick T. Fueger   +3 more
doaj   +1 more source

Islet Culture/Preservation before Islet Transplantation [PDF]

Cell Medicine, 2015
Although islet culture prior to transplantation provides flexibility for the evaluation of isolated islets and the pretreatment of patients, it is well known that isolated islets deteriorate rapidly in culture. Human serum albumin (HSA) is used for medium supplementation instead of fetal bovine serum (FBS), which is typically used for islet culture ...
Hirofumi, Noguchi, Chika, Miyagi-Shiohira, Kiyoto, Kurima, Naoya, Kobayashi, Issei, Saitoh, Masami, Watanabe, Yasufumi, Noguchi, Masayuki, Matsushita   +7 more
openaire   +2 more sources