Results 1 to 10 of about 192,930 (304)

Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis

BMC Medicine, 2022
Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent.
Ehsan Alvandi, Wilson K. M. Wong, Mugdha V. Joglekar, Kevin J. Spring, Anandwardhan A. Hardikar   +4 more
doaj   +1 more source

Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes

Frontiers in Endocrinology, 2023
Cystic fibrosis (CF) is a multi-organ disease caused by loss-of-function mutations in CFTR (which encodes the CF transmembrane conductance regulator ion channel).
Sarah S. Malik, Sarah S. Malik, Diksha Padmanabhan, Diksha Padmanabhan, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle   +7 more
doaj   +1 more source

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Frontiers in Cell and Developmental Biology, 2022
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. Using
Federica Fantuzzi, Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop, Miriam Cnop   +19 more
doaj   +1 more source

Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells

Metabolites, 2021
Pancreatic β cells secrete the hormone insulin into the bloodstream and are critical in the control of blood glucose concentrations. β cells are clustered in the micro-organs of the islets of Langerhans, which have a rich capillary network.
Louise Cottle, Ian Gilroy, Kylie Deng, Thomas Loudovaris, Helen E. Thomas, Anthony J. Gill, Jaswinder S. Samra, Melkam A. Kebede, Jinman Kim, Peter Thorn   +9 more
doaj   +1 more source

Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death

Metabolites, 2023
A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely ...
Yi-Chun Chen, Andrew J. Lutkewitte, Halesha D. Basavarajappa, Patrick T. Fueger   +3 more
doaj   +1 more source

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

Cells, 2021
The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion.
Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro   +8 more
doaj   +1 more source

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

eLife, 2023
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dynamics ...
Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie   +9 more
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Variation in Human Islet Viability Based on Different Membrane Integrity Stains

Cell Transplantation, 2004
Membrane integrity fluorescent staining is used routinely to evaluate islet viability. Results are used as one of the determining factors in islet product release criteria, and are used to assess the efficacy of different culture conditions. Recently, it
M. J. Barnett, D. Mcghee-Wilson, A. M. J. Shapiro, J. R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

A Minimally-invasive Blood-derived Biomarker of Oligodendrocyte Cell-loss in Multiple Sclerosis

EBioMedicine, 2016
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Minimally invasive biomarkers of MS are required for disease diagnosis and treatment. Differentially methylated circulating-free DNA (cfDNA) is a useful biomarker
John A. Olsen, Lauren A. Kenna, Regine C. Tipon, Michael G. Spelios, Mark M. Stecker, Eitan M. Akirav   +5 more
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The regulatory effect and molecular mechanism of lncRNA Gm10451 on islet cell dysfunction in children with diabetes

Frontiers in Genetics, 2022
The dysfunction of islet β-cells is one of the causes of diabetes, and lncRNA Gm10451 is also a participant in the occurrence and the development of various diseases. This study was carried out to reveal the correlation within β-cells and Gm10451.
Jiao Wang, Jiao Wang, Li-hai Zhang, Li-hai Zhang, Yu-ming Kang, Xian-he Wang, Chun-yu Jiang   +6 more
doaj   +1 more source