Results 11 to 20 of about 192,930 (304)

Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. [PDF]

, 2014
Polycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes.
Abbott, David H, Dumesic, Daniel A, Grogan, Tristan, Nicol, Lindsey E, O'Brien, Timothy D, Tarantal, Alice F   +5 more
core   +14 more sources

Islet Culture/Preservation before Islet Transplantation [PDF]

Cell Medicine, 2015
Although islet culture prior to transplantation provides flexibility for the evaluation of isolated islets and the pretreatment of patients, it is well known that isolated islets deteriorate rapidly in culture. Human serum albumin (HSA) is used for medium supplementation instead of fetal bovine serum (FBS), which is typically used for islet culture ...
Hirofumi, Noguchi, Chika, Miyagi-Shiohira, Kiyoto, Kurima, Naoya, Kobayashi, Issei, Saitoh, Masami, Watanabe, Yasufumi, Noguchi, Masayuki, Matsushita   +7 more
openaire   +2 more sources

Fresh Islets are more Effective for Islet Transplantation than Cultured Islets [PDF]

Cell Transplantation, 2012
For clinical islet transplantation, isolated islets deteriorate rapidly in culture, although culturing islets prior to transplantation provides flexibility for evaluation of isolated islets and pretreatment of patients. In the present study, we compared human fresh islets to cultured islets with in vitro and in vivo assays.
Hirofumi Noguchi M.D., Ph.D., Bashoo Naziruddin, Andrew Jackson, Masayuki Shimoda, Tetsuya Ikemoto, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Nicholas Onaca, Marlon F. Levy, Shinichi Matsumoto   +14 more
openaire   +3 more sources

Targeting pancreatic islet NLRP3 improves islet graft revascularization

Diabetes, 2022
<p>  </p> <p>Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain (NOD)-like receptor protein (NLRP)3 inflammasome is expressed in pancreatic ...
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D.A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo   +12 more
openaire   +2 more sources

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

Intramuscular islet transplantation promotes restored islet vascularity [PDF]

Islets, 2011
In a recent publication, we reported that islets transplanted to mouse striated muscle became revascularized with intra-islet vessel densities comparable to native islets. Revascularization of islet grafts was completely dependent on recruited Gr-1+ leukocytes.
Christoffersson G, Carlsson PO, Phillipson M   +2 more
openaire   +3 more sources

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry, GF Bottazzo, GF Bottazzo, GS Eisenbarth, J Satoh, MA Atkinson, MR Christie, P Casali, PG Colman, R Gianani, RC Nayak, RJ Tuson, RL Sorenson, S Baekkeskov, S Baekkeskov, S Genovese, W Richter, W Richter, W Richter, WA Scherbaum   +19 more
core   +1 more source

Human islet isolation and allotransplantation in 22 consecutive cases [PDF]

, 1992
This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer.
Alejandro, R, Carroll, PB, Demetris, AJ, Fung, JJ, Mintz, DH, Ricordi, C, Rodriguez Rilo, HL, Shapiro, R, Starzl, TE, Tzakis, AG, Zeng, Y   +10 more
core   +1 more source

No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years [PDF]

, 1991
Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for ...
A Tarn, A Toniolo, B. O. Boehm, DK Wagener, E Bonifacio, E. F. Pfeiffer, E. Heinze, EJ Rayfield, G Antoniadis, G Frisk, G Kuglin, H Champsaur, H. Egle, H. Hauner, J Karjalainen, J Seißler, J-W Yoon, J. E. Banatvala, J. Sei�ler, JE Banatvala, K Helmke, KP Ratzmann, M. Gl�ck, ML King, P. Muir, R Gladisch, S Srikanta, T Tuvemo, T Tuvemo, W. A. Scherbaum, W. Hampl, WA Scherbaum, WJ Riley   +32 more
core   +1 more source

Superiority of Small Islets in Human Islet Transplantation [PDF]

Diabetes, 2007
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior to large islets both in vitro and in vivo.
Lehmann, R, Zuellig, R A, Kugelmeier, P, Baenninger, P B, Moritz, W, Perren, A, Clavien, P A, Weber, M, Spinas, G A   +8 more
openaire   +3 more sources