Results 31 to 40 of about 192,930 (304)

Methods of Human Islet Culture for Transplantation

Cell Transplantation, 2004
The ability to maintain isolated human islet preparations in tissue culture has recently been adopted by most islet transplant centers, and improves the safety as well as the practicality of islet transplantation. Maintaining islet viability and recovery,
T. B. Murdoch, D. McGhee-Wilson, A. M. J. Shapiro, J. R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

Inhibition of Y1 receptor signaling improves islet transplant outcome [PDF]

, 2017
Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation.
A Ali-Rachedi, A Thonpho, AD Nguyen, AG Nieuwenhuizen, AM Shapiro, AM Shapiro, American Diabetes, A., AR Saltiel, C Ammala, C Postic, C Ricordi, C Ricordi, CR Gustavsen, D Boey, D Boey, D Ize-Ludlow, DL Eizirik, DM Sousa, E Karra, G Bertrand, H Matsuda, H Yajima, HA Wieland, J Cantley, JM Sosenko, JY Kim, K Loh, K Yang, L Zhang, L Zhang, LA Selbie, M Jackerott, N Butta, O Idevall-Hagren, RA Stokes, RL Batterham, RP Robertson, S Kassis, S Seino, S Walters, T Yada, TL Belle van, TT Ngo, W Shao, Y Kashima, YC Shi, YC Shi   +46 more
core   +5 more sources

Comparison of Cooling Systems during Islet Purification

Cell Transplantation, 2006
Islet isolation is a complex procedure that includes digestion and purification of pancreatic tissue. As we move towards clinical regulatory control and standardization, understanding of the detailed stages of the procedure have become increasingly ...
Sue Swift, Tatsuya Kin, Mohammadreza Mirbolooki, Richard Wilson, Jonathan R. T. Lakey Ph.D.   +4 more
doaj   +1 more source

Inducible Mosaic Cell Labeling Provides Insights Into Pancreatic Islet Morphogenesis

Frontiers in Cell and Developmental Biology, 2020
Pancreatic islets, discrete microorgans embedded within the exocrine pancreas, contain beta cells which are critical for glucose homeostasis. Loss or dysfunction of beta cells leads to diabetes, a disease with expanding global prevalence, and for which ...
Julia Freudenblum, Dirk Meyer, Robin A. Kimmel   +2 more
doaj   +1 more source

Islet cell transplantation [PDF]

Postgraduate Medical Journal, 2007
Abstract People with type 1 diabetes have normal exocrine pancreatic function, making islet cell rather than whole organ transplantation an attractive option. Achieving insulin independence in type 1 diabetes was the perceived goal of islet cell transplantation.
Srinivasan, P, Huang, G C, Amiel, S A, Heaton, N D   +3 more
openaire   +3 more sources

Detection of Microbial Contamination during Human Islet Isolation

Cell Transplantation, 2007
Current good manufacturing practice (cGMP) islet processing facilities provide an ultraclean environment for the safe production of clinical grade islets for transplantation into immunosuppressed diabetic recipients.
Tatsuya Kin, Shawn Rosichuk, A. M. James Shapiro, Jonathan R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

Pig islets xenotransplantation: recent progress and current perspectives

Frontiers in Surgery, 2014
Islet xenotransplantation is a prospective treatment to bridge the gap between available human cells and needs of patients with diabetes. Pig is the ideal candidate to obtain such available islet cells.
Haitao eZhu, Wanli eWang, Liang eYu, Bo eWang   +3 more
doaj   +1 more source

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease [PDF]

, 2017
Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing,
Arda, H. Efsun, Burns, Vanessa M, Chakravarthy, Harini, Charville, Gregory, Deisseroth, Karl, Efimov, Igor R, Engberg, Kristin, Gu, Xueying, Holzem, Katherine, Hsueh, Brian, Kim, Seung, Pauerstein, Philip, Vogel, Hannes, Wang, Ai-Chi, Ye, Li   +14 more
core   +2 more sources

Evaluating Islet Cell Isolation and Transplantation From Donors Following Medical Assistance in Dying

Transplantation Direct
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors.
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM   +13 more
doaj   +1 more source

Estimation of Pancreas Weight from Donor Variables

Cell Transplantation, 2006
Previous studies have identified several donor factors affecting the outcome of islet isolation. Pancreas weight has not been considered as a donor selection criterion, because a value cannot be obtained prior to organ procurement.
Tatsuya Kin, Travis B. Murdoch, A. M. James Shapiro, Jonathan R. T. Lakey Ph.D.   +3 more
doaj   +1 more source