Results 31 to 40 of about 91,246 (148)

Islet Encapsulation: Strategies to Enhance Islet Cell Functions [PDF]

Tissue Engineering, 2007
Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Although traditional insulin therapy has alleviated the short-term effects, long-term complications are ubiquitous and harmful. For these reasons, alternative treatment options are being developed.
Beck, Jonathan, Angus, Ryan, Madsen, Ben, Britt, David, Vernon, Brent, Nguyen, Kytai T.   +5 more
openaire   +3 more sources

Human Amniotic Epithelial Cells Induce Localized Cell-Mediated Immune Privilege in Vitro: Implications for Pancreatic Islet Transplantation

Cell Transplantation, 2011
Chronic systemic immunosuppression in cell replacement therapy restricts its clinical application. This study sought to explore the potential of cell-based immune modulation as an alternative to immunosuppressive drug therapy in the context of pancreatic
Khalid M. Qureshi, Robert J. Oliver, Michelle B. Paget, Hilary E. Murray, Clifford J. Bailey, Richard Downing   +5 more
doaj   +1 more source

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors

Scientific Reports, 2022
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +1 more source

No mantle formation in rodent islets—The prototype of islet revisited [PDF]

Diabetes Research and Clinical Practice, 2009
Emerging reports on human islets emphasize distinct differences from the widely accepted prototype of rodent islets, raising questions over their suitability for human studies. Here we aim at elucidating architectural differences and similarities of human versus rodent islets.
Michael, Kharouta, Kevin, Miller, Abraham, Kim, Pawel, Wojcik, German, Kilimnik, Arunangsu, Dey, Donald F, Steiner, Manami, Hara   +7 more
openaire   +2 more sources

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes

Nature Communications
Type 1 diabetes (T1D) risk has been associated with enteroviral infections, particularly coxsackieviruses B (CVB). Cellular host factors contributing to virus-induced islet autoimmunity remain unclear.
Shirin Geravandi, Huan Liu, Heena Pahwa, Murali Krishna Madduri, Farah Atawneh, Adib Miraki Feriz, Sahar Rafizadeh, Annabelle Elisabeth Kruf, Mona Khazaei, Pouria Bahrami, David Gotti, Mohamed Elawour, Ruth M. Elgamal, Ausilia Maria Grasso, David Bund, Blaz Lupse, Zahra Azizi, Omar Zabad, Karim Bouzakri, Marc Horwitz, Alberto Pugliese, Kathrin Maedler, Amin Ardestani   +22 more
doaj   +1 more source

Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient

Orphanet Journal of Rare Diseases, 2017
We have recently published on the limited effectiveness of sirolimus as a treatment option for hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR inhibitors provide new opportunities for the treatment of patients with ...
Indraneel Banerjee, Diva De Leon, Mark J. Dunne   +2 more
doaj   +1 more source

Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis

BMC Medicine
Background Early identification and management of sight-threatening ocular complications of diabetes using imaging or molecular biomarkers could help prevent vision loss.
Mya Polkamp, Nhan H. T. Pham, Wilson K. M. Wong, Hrishikesh P. Hardikar, Pooja S. Kunte, Morven A. Cameron, Anandwardhan A. Hardikar, Mugdha V. Joglekar   +7 more
doaj   +1 more source

Islet Transplantation in the UK [PDF]

CellR4, 2019
This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
P. Johnson, On behalf of the UK Islet Transplant Consortium (UKITC)   +1 more
doaj   +1 more source

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization [PDF]

Diabetes, 2011
OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of functional blood vessels after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization ...
Nyqvist, D., Speier, S., Rodriguez-Diaz, R., Molano, R. D., Lipovsek, S., Rupnik, M., Dicker, A., Ilegems, E., Zahr-Akrawi, E., Molina, J., Lopez-Cabeza, M., Villate, S., Abdulreda, M. H., Ricordi, C., Caicedo, A., Pileggi, A., Berggren, P.-O.   +16 more
openaire   +2 more sources

Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands

Frontiers in Endocrinology, 2016
In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy.
Munirah Mohamad Santosa, Blaise Su Jun Low, Nicole Min Qian Pek, Adrian Kee Keong Teo   +3 more
doaj   +1 more source