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Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]
, 2012 Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
David Epstein +9 more
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Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?
Cells, 2021 Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune destruction or the dysfunction of insulin-producing pancreatic beta cells.
Stephanie Bourgeois +7 more
doaj +1 more source
European Endocrinology, 2017 ‘B eta-cell failure’ is a frequently used term to describe the structural and functional inability of the cells to fulfil their metabolic responsibility. This editorial reviews the anatomy and physiology of the beta cell, and describes factors which regulate this.
Kalra, Sanjay, Gupta, Yashdeep
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Alpha Cells Beget Beta Cells [PDF]
Cell, 2009 Understanding the origins of insulin-producing beta cells of the pancreas could lead to new treatments for diabetes. Collombat et al. (2009) now show that in response to injury, a population of pancreatic progenitor cells can give rise to glucagon-expressing alpha cells that then transdifferentiate into beta cells.
Liu, Zhengyu, Habener, Joel F.
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Frontiers in Endocrinology, 2021 The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene.
Juan Ignacio Burgos +2 more
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Biomedicines, 2023 Cystic fibrosis-related diabetes (CFRD) is a complication associated with a negative prognosis in patients with cystic fibrosis (CF). Although the oral glucose tolerance test (OGTT) is the widely recommended screening test for CFRD diagnosis, continuous ...
Fernando Sebastian-Valles +7 more
doaj +1 more source
Building Better Beta Cells [PDF]
Cell Stem Cell, 2008 Type 1 diabetes represents an attractive target for human embryonic stem cell (hESC)-based cell replacement therapies. Recently, in Nature Biotechnology, Kroon et al. (2008) reported encouraging progress toward this goal with the development of functional islet-like structures in mice transplanted with hESC-derived pancreatic endoderm.
Stanley, Edouard G., Elefanty, Andrew G.
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Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells [PDF]
Scientific Reports, 2021 AbstractPancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell mass and increasing insulin secretion. Previously, using a transgenic mouse with global, heterozygous deletion of prolactin receptor (Prlr+/−), we found Prlr signaling is important for this adaptation. However, since Prlr is expressed in tissues outside of islets
Vipul Shrivastava +6 more
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Frontiers in Endocrinology, 2021 Restoring the number of glucose-responsive β-cells in patients living with diabetes is critical for achieving normoglycemia since functional β-cells are lost during the progression of both type 1 and 2 diabetes.
Amanda Oakie +2 more
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Frontiers in Endocrinology, 2022 Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community.
Viljem Pohorec +5 more
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