Results 31 to 40 of about 2,087,290 (305)
Intrahepatic Islet Transplant in the Mouse: Functional and Morphological Characterization
Cell Transplantation, 2008 Although in a clinical setting islet transplantation is normally performed by percutaneous intrahepatic infusion, the kidney capsule has been the site of choice in nearly all the studies using mice.
R. Melzi +5 more
doaj +1 more source
Cells, 2021 The pancreatic islets of Langerhans secrete several hormones critical for glucose homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete insulin, the only hormone capable of lowering the plasma glucose concentration. The
Petronel Tuluc +3 more
doaj +1 more source
Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas
Cell Transplantation, 2013 The current epidemic of diabetes with its overwhelming burden on our healthcare system requires better therapeutic strategies. Here we present a promising novel approach for a curative strategy that may be accessible for all insulin-dependent diabetes ...
Uriel Barkai Ph.D. +20 more
doaj +1 more source
Roles of lncRNAs in Pancreatic Beta Cell Identity and Diabetes Susceptibility
Frontiers in Genetics, 2014 Type 2 Diabetes usually ensues from the inability of pancreatic beta cells to compensate for incipient insulin resistance. The loss of beta cell mass, function and potentially beta cell identity contribute to this dysfunction to extents which are debated.
Timothy James Pullen, Guy Allen Rutter
doaj +1 more source
Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review
Frontiers in Endocrinology, 2022 In the last decades, obesity has reached epidemic proportions worldwide. Obesity is a chronic disease associated with a wide range of comorbidities, including insulin resistance and type 2 diabetes mellitus (T2D), which results in significant burden of ...
José Ignacio Martínez-Montoro +6 more
doaj +1 more source
Cell Transplantation, 2011 Pleomorphic adenoma gene-like 1 (PLAGL1) has been linked to transient neonatal diabetes mellitus. Here, we investigated the role of the related pleomorphic adenoma gene 1 (PLAG1) in glucose homeostasis.
Jeroen Declercq +15 more
doaj +1 more source
Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny
Journal of Lipid Research, 2008 Nutrition during fetal life is a critical factor contributing to diabetes development in adulthood. The aim of our study was to verify: 1) whether a high-fat (HF) diet in young adult mice induces alterations in β-cell mass, proliferation, neogenesis, and
Donatella Gniuli +6 more
doaj +1 more source
Boosting Beta-Cell Numbers [PDF]
New England Journal of Medicine, 2008 The introduction of three transcription factors into the pancreatic acinar cell of the mouse induces transdifferentiation to an insulin-secreting beta cell.
openaire +2 more sources
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
eLife, 2014 Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum +9 more
doaj +1 more source
Cell therapies for pancreatic beta-cell replenishment [PDF]
Italian Journal of Pediatrics, 2016 The current treatment approach for type 1 diabetes is based on daily insulin injections, combined with blood glucose monitoring. However, administration of exogenous insulin fails to mimic the physiological activity of the islet, therefore diabetes often progresses with the development of serious complications such as kidney failure, retinopathy and ...
OKERE, Bernard +3 more
openaire +4 more sources