Results 11 to 20 of about 2,087,290 (305)
From Beta Cell Replacement to Beta Cell Regeneration [PDF]
Journal of Diabetes Science and Technology, 2014 Diabetes is affecting more than 25.8 million people in the United States, causing huge burden on the health care system and economy. Insulin injection, which is the predominant treatment for diabetes, is incapable of replenishing the lost insulin-producing beta cell in patients.
Chengcheng, Liu, Hao, Wu
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Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels
European Journal of Histochemistry, 2010 The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a homeodomain transcription factor, which is critical for pancreas formation as well as for normal ...
T. Galbo +6 more
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Diabetes-Modifying Antirheumatic Drugs: The Roles of DMARDs as Glucose-Lowering Agents
Medicina, 2022 Systemic inflammation represents a shared pathophysiological mechanism which underlies the frequent clinical associations among chronic inflammatory rheumatic diseases (CIRDs), insulin resistance, type 2 diabetes (T2D), and chronic diabetes complications,
Marco Infante +6 more
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SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]
, 2009 CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M. +3 more
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Cells, 2021 Ongoing beta cell death in type 1 diabetes (T1D) can be detected using biomarkers selectively discharged by dying beta cells into plasma. microRNA-375 (miR-375) ranks among the top biomarkers based on studies in animal models and human islet ...
Geert A. Martens +11 more
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Beta-cell regeneration from vimentin+/MafB+ cells after STZ-induced extreme beta-cell ablation [PDF]
Scientific Reports, 2015 AbstractLoss of functional beta-cells is fundamental in both type 1 and type 2 diabetes.In situbeta-cell regeneration therefore has garnered great interest as an approach to diabetes therapy. Here, after elimination of pre-existing beta cells by a single high-dose of streptozotocin (STZ), we demonstrated that a considerable amount of beta-like-cells ...
Yu Cheng +7 more
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FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions [PDF]
, 2019 In the root endophyte Serendipita indica, several lectin-like members of the expanded multigene family of WSC proteins are transcriptionally induced in planta and are potentially involved in beta-glucan remodeling at the fungal cell wall.
Becker, S. +8 more
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In vitro dissection of anti-diabetic effects of compound a, a dissociating glucocorticoid receptor ligand [PDF]
Archives of Biological Sciences, 2015 Compound A (CpdA), or 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethyl-ammonium chloride, is a stable analog of the hydroxyl phenyl aziridine precursor found in the Namibian shrub Salsola tuberculatiformis Botschantzev.
Vujičić Milica +4 more
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Alpha cell regulation of beta cell function [PDF]
Diabetologia, 2020 AbstractThe islet of Langerhans is a complex endocrine micro-organ consisting of a multitude of endocrine and non-endocrine cell types. The two most abundant and prominent endocrine cell types, the beta and the alpha cells, are essential for the maintenance of blood glucose homeostasis.
Moede, Tilo +2 more
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Cell Transplantation, 2017 Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate
Cornelis R. Van Der Torren +12 more
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