Results 21 to 30 of about 2,087,290 (305)
BNT162b2 mRNA COVID-19 Vaccine Does Not Impact the Honeymoon Phase in Type 1 Diabetes: A Case Report
Vaccines, 2022 Type 1 diabetes (T1D), which is caused by the autoimmune destruction of insulin-secreting pancreatic beta cells, represents a high-risk category requiring COVID-19 vaccine prioritization. Although COVID-19 vaccination can lead to transient hyperglycemia (
Marco Infante +12 more
doaj +1 more source
A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]
, 2008 Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L. +6 more
core +3 more sources
Characterization of the T cell receptor repertoire causing collagen arthritis in mice [PDF]
, 1993 Collagen type II-induced arthritis (CIA) is generated in susceptible rodent strains by intradermal injections of homologous or heterologous native type II collagen in complete Freund's adjuvant.
Hood, Leroy E. +3 more
core +2 more sources
Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function
Frontiers in Endocrinology, 2021 Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand the etiology of the disease or to develop satisfactory treatments.
Livia López–Noriega +2 more
doaj +1 more source
Diabetologia, 1997 heralded as the ideal therapy for the treatment of patients with insulin-dependent diabetes mellitus (IDDM) since it is a relatively safe procedure which should obviate the need for exogenous insulin therapy. More importantly, the resultant euglycaemia should prevent, and possibly even reverse, the devastating secondary complications of the disease ...
N. M. Desai +3 more
openaire +1 more source
The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]
, 2016 Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa +11 more
core +3 more sources
Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]
, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael +8 more
core +2 more sources
Role of CCL2/MCP-1 in Islet Transplantation
Cell Transplantation, 2010 High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence ...
Raffaella Melzi +10 more
doaj +1 more source
Biomolecules, 2021 Serum accumulation of the gut microbial metabolite trimethylamine N-oxide (TMAO) is associated with high caloric intake and type 2 diabetes (T2D). Impaired pancreatic β-cell function is a hallmark of diet-induced T2D, which is linked to hyperglycemia and
Emily S. Krueger +8 more
doaj +1 more source
50 years forward: beta cells [PDF]
Diabetologia, 2015 Our understanding of beta cell development and function has increased substantially these past 50 years but much remains to be learned before this knowledge can be put to clinical use. A comprehensive business plan will be necessary to develop a detailed molecular and functional blueprint of the beta cell in health and disease based on an integrated ...
openaire +3 more sources