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Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. [PDF]
, 1991 The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction.
Tan, L, Turner, J, Weiss, A
core +1 more source
β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]
, 2014 Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L +5 more
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CellsCytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D.
Vinny Negi +13 more
doaj +1 more source
Cells, 2022 Type 1 diabetes (T1D) is an autoimmune disease with immune cells’ islet infiltration (called “insulitis”), which leads to beta cell loss. Despite being the critical element of T1D occurrence and pathogenesis, insulitis is often present in a limited ...
Marcella La Noce +4 more
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Using routinely collected patient data to study the impact of type 2 diabetes on breast cancer
Endocrine OncologyObjective: Type 2 diabetes mellitus (T2DM) and cancer are prevalent conditions, with evidence linking T2DM to higher breast cancer incidence and mortality.
Ayaan Khurshed +4 more
doaj +1 more source
Frontiers in Endocrinology, 2023 IntroductionAn insufficient functional beta cell mass is a core pathological hallmark of type 2 diabetes (T2D). Despite the availability of several effective pharmaceuticals for diabetes management, there is an urgent need for novel medications to ...
Azam Mahmoudi-Aznaveh +5 more
doaj +1 more source
Science, 2019 Aging Removal of senescent cells, which accumulate during aging, may have clinical utility in managing chronic diseases. One chronic disease commonly associated with aging is type 2 diabetes. Diabetes develops when pancreatic beta cells age and senesce, which then contributes to failure of glucose homeostasis. Aguayo-Mazzucato et al.
openaire +1 more source
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. [PDF]
, 2008 ObjectiveThe aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass.Research design and methodsWe analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat ...
Bhushan, Anil +3 more
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Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. [PDF]
, 1995 The extraordinary specificity of bile duct destruction in primary biliary cirrhosis (PBC) and the presence of T cell infiltrates in the portal tracts have suggested that biliary epithelial cells are the targets of an autoimmune response.
Ansari, A +10 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song +15 more
wiley +1 more source