Results 21 to 30 of about 47,870 (244)
eLife, 2023 Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dynamics ...
Christopher H Emfinger +9 more
doaj +1 more source
No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years [PDF]
, 1991 Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for ...
Muir, Peter +10 more
core +1 more source
Outcomes of Islet Autotransplantation in Chronic Pancreatitis Patients with Complete Acinar Atrophy
Cell Transplantation, 2020 Total pancreatectomy with islet autotransplantation (TPIAT) is a promising treatment for refractory chronic pancreatitis (CP). Pathological features of CP include progressive fibrosis in pancreas parenchyma, atrophy, and/or ductal occlusion.
Gumpei Yoshimatsu MD, PhD +8 more
doaj +1 more source
Frontiers in Genetics, 2022 The dysfunction of islet β-cells is one of the causes of diabetes, and lncRNA Gm10451 is also a participant in the occurrence and the development of various diseases. This study was carried out to reveal the correlation within β-cells and Gm10451.
Jiao Wang +6 more
doaj +1 more source
Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]
, 2005 Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Jeremy P. +14 more
core +1 more source
eLife, 2023 Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels.
Wilma Tixi +14 more
doaj +1 more source
Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome [PDF]
, 1993 Cytoplasmic islet cell antibodies are well-established predictive markers of IDDM. Although target molecules of ICA have been suggested to be gangliosides, human monoclonal ICA of the immunoglobulin G class (MICA 1-6) produced from a patient with newly ...
Seißler, Jochen +5 more
core +1 more source
Methods of Human Islet Culture for Transplantation
Cell Transplantation, 2004 The ability to maintain isolated human islet preparations in tissue culture has recently been adopted by most islet transplant centers, and improves the safety as well as the practicality of islet transplantation. Maintaining islet viability and recovery,
T. B. Murdoch +3 more
doaj +1 more source
Slovenian Veterinary Research, 2023 The pancreas is a complex gland that possesses both endocrine and exo-crine functions. The present study investigated the gross anatomy, histochemical fea-tures, and immunohistochemical expression of insulin, glucagon, somatostatin, and pancreatic ...
Ahmed Abdellatif
doaj +1 more source
Islet assessment for transplantation [PDF]
Current Opinion in Organ Transplantation, 2009 There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation. Development, testing, and validation of such assays have been the subject of intense investigation for the last decade. These efforts are reviewed, highlighting the most recent results while
Papas, Klearchos K. +2 more
openaire +4 more sources