Results 41 to 50 of about 47,870 (244)

Epidemiology and immunogenetic background of islet cell antibody - positive nondiabetic schoolchildren : Ulm-Frankfurt population study [PDF]

, 1991
Islet cell antibodies (ICAs) were determined in a large cohort of white nondiabetic schoolchildren (n = 4287) from a homogenous population in southern Germany.
Glück, Michael, Schöffling, Karl, Trucco, Massimo, Seißler, Jochen, Böhm, Bernhard Otto, Holzberger, G., Scherbaum, Werner A., Seidl, S., Manfras, Burkhard J., Kühnl, Peter   +9 more
core   +1 more source

Human Amniotic Epithelial Cells Induce Localized Cell-Mediated Immune Privilege in Vitro: Implications for Pancreatic Islet Transplantation

Cell Transplantation, 2011
Chronic systemic immunosuppression in cell replacement therapy restricts its clinical application. This study sought to explore the potential of cell-based immune modulation as an alternative to immunosuppressive drug therapy in the context of pancreatic
Khalid M. Qureshi, Robert J. Oliver, Michelle B. Paget, Hilary E. Murray, Clifford J. Bailey, Richard Downing   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors

Scientific Reports, 2022
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +1 more source

No mantle formation in rodent islets—The prototype of islet revisited [PDF]

Diabetes Research and Clinical Practice, 2009
Emerging reports on human islets emphasize distinct differences from the widely accepted prototype of rodent islets, raising questions over their suitability for human studies. Here we aim at elucidating architectural differences and similarities of human versus rodent islets.
Michael, Kharouta, Kevin, Miller, Abraham, Kim, Pawel, Wojcik, German, Kilimnik, Arunangsu, Dey, Donald F, Steiner, Manami, Hara   +7 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes

Nature Communications
Type 1 diabetes (T1D) risk has been associated with enteroviral infections, particularly coxsackieviruses B (CVB). Cellular host factors contributing to virus-induced islet autoimmunity remain unclear.
Shirin Geravandi, Huan Liu, Heena Pahwa, Murali Krishna Madduri, Farah Atawneh, Adib Miraki Feriz, Sahar Rafizadeh, Annabelle Elisabeth Kruf, Mona Khazaei, Pouria Bahrami, David Gotti, Mohamed Elawour, Ruth M. Elgamal, Ausilia Maria Grasso, David Bund, Blaz Lupse, Zahra Azizi, Omar Zabad, Karim Bouzakri, Marc Horwitz, Alberto Pugliese, Kathrin Maedler, Amin Ardestani   +22 more
doaj   +1 more source

Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient

Orphanet Journal of Rare Diseases, 2017
We have recently published on the limited effectiveness of sirolimus as a treatment option for hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR inhibitors provide new opportunities for the treatment of patients with ...
Indraneel Banerjee, Diva De Leon, Mark J. Dunne   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J., Ong, Wee Kiat, Furman, Brian   +2 more
core   +4 more sources