Results 41 to 50 of about 192,930 (304)
Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. [PDF]
, 2016 Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however ...
Bhushan, Anil +3 more
core +1 more source
Pharmaceutics, 2021 Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells.
Gianmarco Ferri +10 more
doaj +1 more source
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets [PDF]
, 2015 This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.AIMS/HYPOTHESIS: Ageing can lead to reduced insulin sensitivity and loss of pancreatic beta cell function ...
Allagnat, F +7 more
core +3 more sources
Cell Transplantation, 2017 This study investigates manufacturing procedures that affect islet isolation outcomes from donor pancreata standardized by the North American Islet Donor Score (NAIDS).
Chun-Chieh Yeh +12 more
doaj +1 more source
Scientific Reports, 2022 The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst +3 more
doaj +1 more source
Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient
Orphanet Journal of Rare Diseases, 2017 We have recently published on the limited effectiveness of sirolimus as a treatment option for hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR inhibitors provide new opportunities for the treatment of patients with ...
Indraneel Banerjee +2 more
doaj +1 more source
Pancreatic islet transplantation [PDF]
World Journal of Gastrointestinal Surgery, 2009 Type 1 diabetes mellitus is an autoimmune disease, which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans. While exogenous insulin therapy has dramatically improved the quality of life, chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and ...
Corrêa-Giannella Maria +1 more
openaire +5 more sources
Islet Transplantation in the UK [PDF]
CellR4, 2019 This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
P. Johnson +1 more
doaj +1 more source
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source