Results 41 to 50 of about 91,246 (148)
Non-Islet Origin of Pancreatic Islet Cell Tumors [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2004 The histogenesis of pancreatic islet cell tumors was investigated by morphological identification of putative precursor lesions in pancreatic tissue from patients with multiple endocrine neoplasia type 1 (MEN1), tissue microdissection, and genetic analysis.
Alexander O, Vortmeyer +3 more
openaire +2 more sources
Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel
Cell TransplantationHuman islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell–derived beta-like cells.
Anna French +6 more
doaj +1 more source
Biomedicines, 2023 CaV3 channels are ontogenetically downregulated with the maturation of certain electrically excitable cells, including pancreatic β cells. Abnormally exaggerated CaV3 channels drive the dedifferentiation of mature β cells. This led us to question whether
Kaixuan Zhao +10 more
doaj +1 more source
β-Cell Death in Diabetes: Past Discoveries, Present Understanding, and Potential Future Advances
Metabolites, 2021 β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and potential future advances in our understanding of the mechanisms that
Noyonika Mukherjee +3 more
doaj +1 more source
Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion
Frontiers in Neuroscience, 2019 Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural ...
Wenjing Li +3 more
doaj +1 more source
Assessment of islet function following islet and pancreas transplantation [PDF]
Current Diabetes Reports, 2006 Pancreas and islet transplant recipients are monitored using various metabolic and imaging methods. The inaccessibility of the transplanted whole pancreas and of the isolated islets poses specific problems (eg, all assessment techniques are indirect).
Emily C, Dy +2 more
openaire +2 more sources
Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function [PDF]
Current Diabetes Reports, 2015 Islets of Langerhans contain multiple hormone-producing endocrine cells controlling glucose homeostasis. Transcription establishes and maintains islet cellular fates and identities. Genetic and environmental disruption of islet transcription triggers cellular dysfunction and disease.
Stitzel, Michael L +3 more
openaire +2 more sources
Intermittent intraperitoneal implantation of islets in rat islet transplantation
Cell Transplantation, 1996 Two critical issues need to be addressed regarding islet cell transplantation: obtaining sufficient supply of cells for implantation, and the maintenance of the viability of these cells. Our present study has two protocols. One is islet cell implantation under the renal capsule, and the other, repeated injection of islet cells into the peritoneal ...
K, Okugawa +8 more
openaire +2 more sources
Stem Cell Reports, 2017 Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of “healthy” human donor pancreata restricts the broader application of this effective curative therapy.
Andrew R. Pepper +10 more
doaj +1 more source
Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response
iScience, 2018 Summary: Impaired pancreatic β-cell survival contributes to the reduced β-cell mass in diabetes, but underlying regulatory mechanisms and key players in this process remain incompletely understood.
Kanaka Durga Devi Gorrepati +5 more
doaj +1 more source