Results 51 to 60 of about 47,870 (244)

Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis

BMC Medicine
Background Early identification and management of sight-threatening ocular complications of diabetes using imaging or molecular biomarkers could help prevent vision loss.
Mya Polkamp, Nhan H. T. Pham, Wilson K. M. Wong, Hrishikesh P. Hardikar, Pooja S. Kunte, Morven A. Cameron, Anandwardhan A. Hardikar, Mugdha V. Joglekar   +7 more
doaj   +1 more source

Islet Transplantation in the UK [PDF]

CellR4, 2019
This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
P. Johnson, On behalf of the UK Islet Transplant Consortium (UKITC)   +1 more
doaj   +1 more source

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization [PDF]

Diabetes, 2011
OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of functional blood vessels after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization ...
Nyqvist, D., Speier, S., Rodriguez-Diaz, R., Molano, R. D., Lipovsek, S., Rupnik, M., Dicker, A., Ilegems, E., Zahr-Akrawi, E., Molina, J., Lopez-Cabeza, M., Villate, S., Abdulreda, M. H., Ricordi, C., Caicedo, A., Pileggi, A., Berggren, P.-O.   +16 more
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands

Frontiers in Endocrinology, 2016
In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy.
Munirah Mohamad Santosa, Blaise Su Jun Low, Nicole Min Qian Pek, Adrian Kee Keong Teo   +3 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Effect of Adenosine on the Morphological and Functional Integrity of Isolated Human Islets Exposed to Normoxic and Hypoxic Conditions

Bioengineering
Adenosine is a ubiquitous stress marker and is characterised by numerous vital functions in all organs. Although adenosine has been investigated for decades, the information about its metabolism in islet cells has mainly been obtained in rodents.
Heide Brandhorst, Daniel Brandhorst, Rebecca Spiers, Samuel Acreman, Lucian Christopherson, Anthony Cornu, Artjoms Portnojs, Keith Al-Hasani, Paul R. V. Johnson   +8 more
doaj   +1 more source

Non-Islet Origin of Pancreatic Islet Cell Tumors [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2004
The histogenesis of pancreatic islet cell tumors was investigated by morphological identification of putative precursor lesions in pancreatic tissue from patients with multiple endocrine neoplasia type 1 (MEN1), tissue microdissection, and genetic analysis.
Alexander O, Vortmeyer, Steve, Huang, Irina, Lubensky, Zhengping, Zhuang   +3 more
openaire   +2 more sources

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel

Cell Transplantation
Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell–derived beta-like cells.
Anna French, Jennifer Hollister-Lock, Brooke A. Sullivan, Eline Stas, Albert J. Hwa, Gordon C. Weir, Susan Bonner-Weir   +6 more
doaj   +1 more source