Upconverting Nanoparticles for Bimodal Luminescence and Magnetic Resonance Imaging of Langerhans Islets [PDF]
Small ScienceCombining luminescence with magnetic resonance imaging (MRI) is a noninvasive approach that significantly improves detection sensitivity and diagnostic precision for severe diseases. In diabetes care, this approach considerably broadens the possibilities
Oleksandr Shapoval +9 more
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Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering. [PDF]
Diabetes Metab Res RevABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Sabet Sarvestani F +4 more
europepmc +2 more sources
Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. [PDF]
PLoS ONE, 2013 Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction ...
Mijke Buitinga +8 more
doaj +4 more sources
Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co-Cultures Maintains Their Function in a Hypoxic Environment. [PDF]
Adv Healthc MaterThis study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Dani F +7 more
europepmc +2 more sources
Mesenchymal Stromal Cells Improve Islet β-Cell Functional Survival: Analysis of Extracellular Vesicle-Trafficked Proteins and miRNAs [PDF]
CellsType 1 diabetes is caused by autoimmune destruction of insulin-secreting β-cells within islets of Langerhans. Transplantation of donor islets can improve glycaemic control, but current clinical islet transplantation protocols are compromised by extensive
Tzu-Wen Hong +11 more
doaj +2 more sources
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal [PDF]
The Journal of Clinical InvestigationTransplantation of allogeneic islets of Langerhans, which include the insulin-producing β cells of the endocrine pancreas, holds curative potential for type 1 diabetes (T1D).
Stephen P. Persaud, John F. DiPersio
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Lesió i protecció de les cèl·lules beta en el trasplantament d'illots pancreàtics [PDF]
, 2007 [cat] El trasplantament d'illots pancreàtics pot ser una bona teràpia per els malalts amb diabetis mellitus de tipus 1, però hi ha alguns problemes que cal solventar abans que sigui un tractament estès.
Montolio Rusiñol, Marta
core +6 more sources
The pancreatic islet: a micro-organ in control [PDF]
CellR4, 2021 The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and islet dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and ...
M. Abdulreda, P. Berggren
doaj +1 more source
Protecting islet functional viability using mesenchymal stromal cells
Stem Cells Translational Medicine, 2021 Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes.
Ella L. Hubber +2 more
doaj +1 more source
Surface Coating of Islets of Langerhans by Activated Polyethylene Glycol [PDF]
علوم و تکنولوژی پلیمر, 2008 The final treatment for diabetes is transplantation of islets of Langerhans. One of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol.
S. Hashemi Najafabadi +3 more
doaj +1 more source