Results 11 to 20 of about 6,261 (168)

A DPP6-Targeted PET Tracer for Non-Invasive Imaging of Transplanted Human Islets. [PDF]

Diabetes Obes Metab
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Khalil A, Roca-Rivada A, Vasylovska S, Balestri LJI, Velikyan I, Jawurek S, Title AC, Yesildag B, Odell LR, Lau J, Eizirik DL, Eriksson O.   +11 more
europepmc   +2 more sources

Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering. [PDF]

Diabetes Metab Res Rev
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Sabet Sarvestani F, Yaghobi R, Khosravi Maharlooei M, Golshan M, Karimi MH.   +4 more
europepmc   +2 more sources

Oxidative Stress, Post‐Translational Modifications, and Type 1 Diabetes Pathogenesis [PDF]

Immunol Rev
ABSTRACT Type 1 diabetes (T1D) is an organ‐specific autoimmune disease that destroys insulin‐producing beta‐cells. Insulin is a vital hormone for regulating glycemia that often undergoes post‐translational modifications during processing from pre‐proinsulin to biologically active insulin.
Winstead C, Hodel M, Tse H.
europepmc   +2 more sources

Inflammatory Mediators Expressed in Human Islets of Langerhans: Implications for Islet Transplantation

Biochemical and Biophysical Research Communications, 2003
Olle Korsgren, Bo Nilsson, Susanne Gabrielsson   +2 more
exaly   +3 more sources

Surface Coating of Islets of Langerhans by Activated Polyethylene Glycol [PDF]

علوم و تکنولوژی پلیمر, 2008
The final treatment for diabetes is transplantation of islets of Langerhans. One of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol.
S. Hashemi Najafabadi, E. Vasheghani-Farahani, S.A. Shojasadati, Y. Iwanaga   +3 more
doaj   +1 more source

Protecting islet functional viability using mesenchymal stromal cells

Stem Cells Translational Medicine, 2021
Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes.
Ella L. Hubber, Chloe L. Rackham, Peter M. Jones   +2 more
doaj   +1 more source

Effects of Energy Dissipation Rate on Islets of Langerhans: Implications for Isolation and Transplantation

Biotechnology and Bioengineering, 2009
Klearchos K Papas, Jeffrey J Chalmers, Ruben Godoy-Silva   +2 more
exaly   +3 more sources

Islet of Langerhans Transplantation for the Treatment of Type 1 Diabetes

Swiss Surgery = Schweizer Chirurgie = Chirurgie Suisse = Chirurgia Svizzera, 2003
Thierry Berney, Ph Morel, P Bucher
exaly   +3 more sources

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co-Cultures Maintains Their Function in a Hypoxic Environment. [PDF]

Adv Healthc Mater
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Dani F, Duin S, Akkineni AR, Lehmann S, Ludwig B, Kühl M, Gelinsky M, Lode A.   +7 more
europepmc   +2 more sources

Transplante isogênico de ilhotas de Langerhans no fígado de ratos: metodologia para separação e purificação das ilhotas de Langerhans Isogenic islet transplantation on the rat liver: Method for isolation and purification of the rat islets

Arquivos de Gastroenterologia, 2000
A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB, Apostolos PAPALOIS, Ingrid G. M. BRONS, Roy Y. CALNE   +3 more
doaj   +1 more source