Results 41 to 50 of about 6,261 (168)

Redox-Dependent Inflammation in Islet Transplantation Rejection

Frontiers in Endocrinology, 2018
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans.
Jessie M. Barra, Hubert M. Tse
doaj   +1 more source

Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives

Clinical Medicine Insights: Endocrinology and Diabetes, 2019
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy.
Varun Pathak, Nupur Madhur Pathak, Christina L O’Neill, Jasenka Guduric-Fuchs, Reinhold J Medina   +4 more
doaj   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Encapsulation of Islets in Rough Surface, Hydroxymethylated Polysulfone Capillaries Stimulates VEGF Release and Promotes Vascularization after Transplantation

Cell Transplantation, 2005
The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and ...
N. Lembert, J. Wesche, P. Petersen, M. Doser, P. Zschocke, H. D. Becker, H. P. T. Ammon   +6 more
doaj   +1 more source

A Stepwise Method to Derive Functional Pancreatic Islet‐like Clusters from Human Pluripotent Stem Cells

Current Protocols, Volume 6, Issue 9, September 2026.
Abstract The most common treatment for people with people with type 1 diabetes (T1D) requires injections of exogenous insulin to regulate blood glucose homeostasis. A longer‐term therapeutic solution for T1D has emerged whereby patients may regain insulin independence through transplantation of donated human pancreatic islets, which contain insulin ...
Manuj Bandral, Jimena Alvarez‐Castanon, David S. Lorberbaum   +2 more
wiley   +1 more source

3D Collagen Hydrogel Promotes In Vitro Langerhans Islets Vascularization through ad-MVFs Angiogenic Activity

Biomedicines, 2021
Adipose derived microvascular fragments (ad-MVFs) consist of effective vascularization units able to reassemble into efficient microvascular networks.
Monica Salamone, Salvatrice Rigogliuso, Aldo Nicosia, Simona Campora, Carmelo Marco Bruno, Giulio Ghersi   +5 more
doaj   +1 more source

From islet of Langerhans transplantation to the bioartificial pancreas [PDF]

, 2022
Thierry Berney, Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Laura Mar Fonseca, Juliette Bignard, Reine Hanna, Andrea Peloso, Ekaterine Berishvili   +8 more
openalex   +1 more source

Successful Suppression of the Early Rejection of Pig Islets in Monkeys

Cell Transplantation, 2000
Primary nonfunction (PNF) is seen very frequently after xenogeneic transplantation of islets of Langerhans. In a pig-to-rat model we recently observed that no PNF occurs when the islets are kept in culture at 37°C for 1–2 weeks prior to transplantation ...
Josephine K. R. A. Rijkelijkhuizen, Eelco Bouwman, Michel P. M. Van Der Burg, Jan Ringers, Miriam A. Ossevoort, Eva M. Kuhn, Pat Frost, Margreet Jonker   +7 more
doaj   +1 more source

Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions [PDF]

Endocrinology and Metabolism, 2017
Impaired awareness of hypoglycemia has been found to be prevalent in 20% to 40% of people with type 1 diabetes. If a similar prevalence exists in Koreans with type 1 diabetes, at a minimum, thousands of people with type 1 diabetes suffer at least one ...
Sang-Man Jin
doaj   +1 more source

A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation [PDF]

, 2022
Thierry Berney, Axel Andrès, Melena D. Bellin, Eelco J.P. de Koning, Paul Johnson, Thomas W. H. Kay, Torbjörn Lundgren, Michael Roehrhoff Rickels, Hanne Scholz, Peter G. Stock, Steve A. White   +10 more
openalex   +1 more source