Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts [PDF]
, 2010 Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors.
Eichhorn, M. E. +6 more
core +1 more source
Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices
Cell Transplantation, 1992 In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets.
Seh-Huang Chao +3 more
doaj +1 more source
Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions [PDF]
Endocrinology and Metabolism, 2017 Impaired awareness of hypoglycemia has been found to be prevalent in 20% to 40% of people with type 1 diabetes. If a similar prevalence exists in Koreans with type 1 diabetes, at a minimum, thousands of people with type 1 diabetes suffer at least one ...
Sang-Man Jin
doaj +1 more source
The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity
Frontiers in Endocrinology, 2021 The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone regulating glucose uptake and metabolism.
Erwin Ilegems +5 more
doaj +1 more source
Regulation of human pancreas hormone secretion by autonomic innervation [PDF]
, 2012 Diabetes mellitus is a silent killer doing away with one person every 10 seconds. We speak of diabetes when the organism cannot control the right level of glucose in the blood.
Rodriguez-Diaz, Rayner
core +1 more source
Epidemiology and Clinical Impact of Confirmed Respiratory Viral Infections in Solid Organ Transplant Recipients. [PDF]
Transpl Infect DisABSTRACT Background Respiratory viral infections (RVIs) can have distinct clinical presentations and outcomes in non‐lung solid organ transplant (SOT) recipients compared to non‐transplant and lung transplant patients. Understanding their impact is crucial for improving patient care and outcomes.
Prins MLM +11 more
europepmc +2 more sources
Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets [PDF]
, 2018 BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression.
Crossan, Claire +4 more
core +1 more source
Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis [PDF]
, 2012 For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells.
K. Andralojc +8 more
core +1 more source
Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives
Clinical Medicine Insights: Endocrinology and Diabetes, 2019 Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy.
Varun Pathak +4 more
doaj +1 more source
Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat
Cell Transplantation, 1994 Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for ...
Andrew J. Portis +2 more
doaj +1 more source