Results 31 to 40 of about 5,845 (176)

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, Volume 255, Issue 6, Page 567-584, June 2026.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Encapsulation of Islets in Rough Surface, Hydroxymethylated Polysulfone Capillaries Stimulates VEGF Release and Promotes Vascularization after Transplantation

Cell Transplantation, 2005
The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and ...
N. Lembert, J. Wesche, P. Petersen, M. Doser, P. Zschocke, H. D. Becker, H. P. T. Ammon   +6 more
doaj   +1 more source

Successful Suppression of the Early Rejection of Pig Islets in Monkeys

Cell Transplantation, 2000
Primary nonfunction (PNF) is seen very frequently after xenogeneic transplantation of islets of Langerhans. In a pig-to-rat model we recently observed that no PNF occurs when the islets are kept in culture at 37°C for 1–2 weeks prior to transplantation ...
Josephine K. R. A. Rijkelijkhuizen, Eelco Bouwman, Michel P. M. Van Der Burg, Jan Ringers, Miriam A. Ossevoort, Eva M. Kuhn, Pat Frost, Margreet Jonker   +7 more
doaj   +1 more source

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

Journal of Translational Medicine, 2007
While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative.
Li Xin, Harlan David M, Liu Eric, Wang Ena, Jin Ping, Ren Jiaqiang, Stroncek David F   +6 more
doaj   +1 more source

A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation

Transplant International, 2022
A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies.
Berney, T, Andres, A, Bellin, MD, de Koning, EJP, Johnson, PRV, Kay, TWH, Lundgren, T, Rickels, MR, Scholz, H, Stock, PG, White, S, Aghayan, HR, Alejandro, R, Ricordi, C, Anazawa, T, Armanet, M, Cattan, P, Badet, L, Buron, F, Balamurugan, AN, Mokshagundam, SPL, Barton, FB, Benhamou, PY, Lablanche, S, Berishvili, E, Bosco, D, Pernin, N, Wassmer, CH, Bertuzzi, F, Borot, S, Bottino, R, Brendel, MD, Caicedo, LA, Echeverri, GJ, Casey, J, Choudhary, P, Coates, PT, Conget, I, Ventura-Aguiar, P, Cooper, M, Khan, KM, Debska-Slizien, A, Golebiewska, J, Desai, CS, Dominguez-Gil, B, Drago, J, Hyon, SH, Fedaruk, D, Goss, JA, Hering, BJ, Jung, HS, Kanak, MA, Kandeel, F, Kenmochi, T, Kessler, L, Munch, M, Keymeulen, B, Khambalia, H, Kim, JH, Korsgren, O, Kudva, YC, Stegall, MD, Labriola, L, Lee, EY, Yoon, KH, Lehmann, R, Ludwig, B, Lundren, T, Luo, X, Maffi, P, Piemonti, L, Markmann, J, Mattina, A, Meloche, M, Morgan, K, Naziruddin, B, Onaca, N, Odorico, JS, Paraskevas, S, Pattou, F, Vantyghem, MC, Romo, RM, Saudek, F, Shapiro, JAM, Shaw, J, Shimoda, M, Webster, A, Witkowski, P, Wojtusciszyn, A, Wszola, M   +89 more
openaire   +6 more sources

Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. [PDF]

PLoS ONE, 2013
Intrahepatic transplantation of donor islets of Langerhans is a promising therapy for patients with type 1 diabetes. It is of critical importance to accurately monitor islet quality before transplantation, which is currently done by standard histological
Janneke Hilderink, Cees Otto, Cees Slump, Aufried Lenferink, Marten Engelse, Clemens van Blitterswijk, Eelco de Koning, Marcel Karperien, Aart van Apeldoorn   +8 more
doaj   +1 more source

Unlocking beta cell health: The clinical potential of extracellular vesicles in type 1 diabetes

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Extracellular vesicles serve as minimally invasive biomarkers of β‑cell stress and immune dysregulation in T1D. This review highlights the potentials of EVs as a biomarker to improve early detection and disease staging in type 1 diabetes. Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune disease characterised by progressive immune ...
Nanthini Jayabalan, Flavio Carrion, Kriti Joshi, Tony Huynh, Carlos Salomon   +4 more
wiley   +1 more source

A Practical Guide to Rodent Islet Isolation and Assessment

Biological Procedures Online, 2009
Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process.
Carter Jeffrey, Dula Stacey, Corbin Kathryn, Wu Runpei, Nunemaker Craig   +4 more
doaj   +3 more sources

A Practical Guide to Rodent Islet Isolation and Assessment Revisited

Biological Procedures Online, 2021
Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is critical for research and transplantation.
Kathryn L. Corbin, Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source