Results 31 to 40 of about 6,261 (168)

Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat

Cell Transplantation, 1994
Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for ...
Andrew J. Portis, Ray V. Rajotte Dr., Teresa L. Krukoff   +2 more
doaj   +1 more source

Influence of the purification of human adult pancreatic islets on insulin secretion [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. The most effective method for human adult pancreatic islets purification is density-gradient centrifugation. The aim of this study was to analyze the effects of non-automated purification on preservation of functional capacity of human ...
Nikolić Dragan M., Đorđević Predrag B., Dimitrijević-Srećković Vesna, Džingalašević Marina, Belij Sandra, Kalezić Nevena   +5 more
doaj   +1 more source

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice

Stem Cell Research & Therapy, 2017
Background Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets.
Elisa Montanari, Raphael P. H. Meier, Redouan Mahou, Jörg D. Seebach, Christine Wandrey, Sandrine Gerber-Lemaire, Leo H. Buhler, Carmen Gonelle-Gispert   +7 more
doaj   +1 more source

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

Journal of Translational Medicine, 2007
While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative.
Li Xin, Harlan David M, Liu Eric, Wang Ena, Jin Ping, Ren Jiaqiang, Stroncek David F   +6 more
doaj   +1 more source

Islet Cell Transplantation: In Vivo and in Vitro Functional Assessment of Nonhuman Primate Pancreatic Islets

Cell Transplantation, 2000
Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections.
Alessandra Rammcoli, Nicola Cautero, Camillo Ricordi, Michele Masetti, Ruth D. Molano, Luca Inverardi, Rodolfo Alejandro, Norma S. Kenyon Ph.D.   +7 more
doaj   +1 more source

Improvement of the functionality of pancreatic Langerhans islets via reduction of bacterial contamination and apoptosis using phenolic compounds [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): During type-1 diabetes treating by pancreatic islet transplantation, increasing oxidative stress and microbial contaminations are the main reasons of transplantation failure.
Mahban Rahimifard, Shermineh Moeini-Nodeh, Kamal Niaz, Maryam Baeeri, Hossein Jamalifar, Mohammad Abdollahi   +5 more
doaj   +1 more source

Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices

Cell Transplantation, 1992
In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets.
Seh-Huang Chao, Madhusudan V. Peshwa, David E.R. Sutherland M.D., Ph.D., Wei-Shou Hu   +3 more
doaj   +1 more source

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Frontiers in Endocrinology, 2021
The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone regulating glucose uptake and metabolism.
Erwin Ilegems, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren   +5 more
doaj   +1 more source

A holistic approach to type 1 diabetes: From advances in science and technology to equity in diabetes care

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source