Results 61 to 70 of about 165,997,933 (148)

Unlocking beta cell health: The clinical potential of extracellular vesicles in type 1 diabetes

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Extracellular vesicles serve as minimally invasive biomarkers of β‑cell stress and immune dysregulation in T1D. This review highlights the potentials of EVs as a biomarker to improve early detection and disease staging in type 1 diabetes. Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune disease characterised by progressive immune ...
Nanthini Jayabalan, Flavio Carrion, Kriti Joshi, Tony Huynh, Carlos Salomon   +4 more
wiley   +1 more source

Studies of clinically applicable human tolerogenic dendritic cells and PD-L2 genetic modification of human islet allograft to promote graft tolerance. [PDF]

, 2011
Islet transplantation is a developing therapy for type 1 diabetic patients (T1D), which has been limited by problems associated with hypoxia, poor revascularisation and allograft rejection.
Rojas-Canales, Darling
core  

Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin

Stem Cell Research & Therapy, 2019
Background Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation.
Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, Frédéric Lamarche, Cécile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou, Sandrine Lablanche   +12 more
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Human islet transplantation - state of the art [PDF]

Einstein (São Paulo), 2005
Currently, only vascularized pancreas transplantation can reestablishlong-term normoglycemia but the scenario has beenassociated with significant morbidity and mortality.
Eleazar Chaib, Joaquim Gama-Rodrigues, Marcelo Augusto Ribeiro Jr, Willian Abrão Saad, Ivan Cecconello   +4 more
doaj  

The Islet Size to Oxygen Consumption Ratio Reliably Predicts Reversal of Diabetes Posttransplant

Cell Transplantation, 2012
β-Cell replacement therapy by either whole-organ pancreas or islets of Langerhans transplantation can restore carbohydrate control to diabetic patients and reduces complications associated with the disease.
Andrew R. Pepper, Craig P. Hasilo, C. W. James Melling, Delfina M. Mazzuca, Greg Vilk, Guangyong Zou, David J. G. White   +6 more
doaj   +1 more source

Intraocular in vivo imaging of pancreatic islet cell physiology/pathology

Molecular Metabolism, 2017
Background: Diabetes mellitus has reached epidemic proportions and requires new strategies for treatment. Unfortunately, the efficacy of treatment regimens on maintaining/re-gaining functional beta cell mass can, at the present, only be determined ...
Ingo B. Leibiger, Per-Olof Berggren
doaj   +1 more source

Follow-up Study of the Revascularization Process of Purified Rat Islet Beta-Cell Grafts

Cell Transplantation, 1997
The revascularization of islets of Langerhans transplanted in heterotopic sites like the liver by portal vein embolization or the renal subcapsular space is a major process necessary for the viability of grafted cells.
José F. Mendola, Ignacio Conget, José María Manzanares, Helena Corominola, Odette Viñas, Juanjo Barcelo, Ramon Gomis   +6 more
doaj   +1 more source

Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs

Journal of Transplantation, 2011
Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of ...
Marc R. Hammerman
doaj   +1 more source