Results 61 to 70 of about 6,261 (168)
Improved Functional Survival of Human Islets of Langerhans in Three-Dimensional Matrix Culture
Cell Transplantation, 1994 The current study evaluates functional survival of human islets maintained in tissue culture for up to 4 wk in suspension media (CMRL-1066 with supplements) and contrasts these results with immobilizing three-dimensional matrices (agarose or alginate ...
Mathias D. Brendel +3 more
doaj +1 more source
Human islet xenotransplantation in rodents: A literature review of experimental model trends
ClinicsAmong the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto +10 more
doaj +1 more source
Unlocking beta cell health: The clinical potential of extracellular vesicles in type 1 diabetes
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Extracellular vesicles serve as minimally invasive biomarkers of β‑cell stress and immune dysregulation in T1D. This review highlights the potentials of EVs as a biomarker to improve early detection and disease staging in type 1 diabetes. Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune disease characterised by progressive immune ...
Nanthini Jayabalan +4 more
wiley +1 more source
A Practical Guide to Rodent Islet Isolation and Assessment
Biological Procedures Online, 2009 Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process.
Carter Jeffrey +4 more
doaj +3 more sources
Gelatin Density Gradient for Isolation of Islets of Langerhans
Cell Transplantation, 1998 Isolation of islets of Langerhans (islets) has been performed by means of collagenase digestion of the pancreatic tissue combined with density gradient separation of islets from unwanted exocrine tissues.
Tadashi Samejima +4 more
doaj +1 more source
IDENTIFICATION OF ISLET CAPACITY IN DONOR’S PANCREAS USING IMMUNOMORPHOLOGICAL ANALYSIS
Вестник трансплантологии и искусственных органов, 2016 The aim of the work was detailed morphological investigations of donor pancreas (DP) for the study of possibilities of maximal selection of islet tissue suitable for transplantation to a patient of diabetes mellitus type 1.Materials and methods.
N. N. Skaletskiy +5 more
doaj +1 more source
Bulk Cryopreservation of Isolated Islets of Langerhans
Cell Transplantation, 1996 Current methods to isolate human islets of Langerhans are limited and multiple donors are required for successful reversal of longstanding Type 1 diabetes mellitus. Cryopreservation of isolated islets is an effective method of storing and pooling islets.
Jonathan R.T. Lakey +3 more
doaj +1 more source
Human islet transplantation - state of the art [PDF]
Einstein (São Paulo), 2005 Currently, only vascularized pancreas transplantation can reestablishlong-term normoglycemia but the scenario has beenassociated with significant morbidity and mortality.
Eleazar Chaib +4 more
doaj
Cell Transplantation, 2006 The measurement of cellular oxygen consumption rate (OCR) is a potential tool for the assessment of metabolic potency of isolated islets of Langerhans prior to clinical transplantation.
Chris Fraker +11 more
doaj +1 more source