Membrane Protein Profiling of Human Islets of Langerhans Using Several Extraction Methods [PDF]
, 2010 Introduction Proteomic characterization of the human pancreatic islets, containing the insulin producing beta-cells, is likely to be of great importance for improved treatment and understanding of the pathophysiology of diabetes mellitus.
Hans Tornqvist +6 more
core +1 more source
Encapsulation of Langerhans' islets: Microtechnological developments for transplantation
Engineering in Life Sciences, 2011 AbstractThere is an increasing trend to apply microsystems and microfluidics to solve medical and biomedical tasks. Microfluidic modules are used to modify and manipulate cells and cell clusters for therapeutic applications. Specifically, a method and technical system for encapsulation of Langerhans' islets as an option for the future treatment of ...
Stefan Wiedemeier +7 more
openaire +1 more source
The Islet Size to Oxygen Consumption Ratio Reliably Predicts Reversal of Diabetes Posttransplant
Cell Transplantation, 2012 β-Cell replacement therapy by either whole-organ pancreas or islets of Langerhans transplantation can restore carbohydrate control to diabetic patients and reduces complications associated with the disease.
Andrew R. Pepper +6 more
doaj +1 more source
Intraocular in vivo imaging of pancreatic islet cell physiology/pathology
Molecular Metabolism, 2017 Background: Diabetes mellitus has reached epidemic proportions and requires new strategies for treatment. Unfortunately, the efficacy of treatment regimens on maintaining/re-gaining functional beta cell mass can, at the present, only be determined ...
Ingo B. Leibiger, Per-Olof Berggren
doaj +1 more source
Pancreatic islets from non-heart beating donor pig: Two-layer preservation method in an in vitro porcine model [PDF]
, 2011 Purpose: Pancreata from non-heart beating donors could represent an unlimited source of islets if their cell viability can be efficiently preserved during the time necessary to process the organs by the use of a better solution of preservation compared ...
Altomare, R. +8 more
core +1 more source
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond
Immunological Reviews, Volume 335, Issue 1, October 2025.ABSTRACT Lymphoid organ development occurs in ontogeny in the absence of antigenic stimulation; inflammation occurs after some immunological insult. These subjects had originally been considered as separate fields of research. Inflammation is due to inflammatory mediators such as lymphotoxin (LT) and its close relative, tumor necrosis factor (TNF). The
Nancy H. Ruddle
wiley +1 more source
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. [PDF]
, 2008 ObjectiveThe aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass.Research design and methodsWe analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat ...
Bhushan, Anil +3 more
core +1 more source
Follow-up Study of the Revascularization Process of Purified Rat Islet Beta-Cell Grafts
Cell Transplantation, 1997 The revascularization of islets of Langerhans transplanted in heterotopic sites like the liver by portal vein embolization or the renal subcapsular space is a major process necessary for the viability of grafted cells.
José F. Mendola +6 more
doaj +1 more source
A role for von Hippel-Lindau protein in pancreatic beta-cell function. [PDF]
, 2009 ObjectiveThe Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.
Cano, David A +2 more
core
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Journal of Transplantation, 2011 Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of ...
Marc R. Hammerman
doaj +1 more source