Results 71 to 80 of about 11,200 (227)

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Clinics
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto, André Silva Franco, Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Juliana Mika Kato, Matheus Belloni Torsani, Alberto Meyer, Wellington Andraus, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +10 more
doaj   +1 more source

One‐Step Coordinated Multi‐Kinetic 4D Printing of Human Vascularized Cardiac Tissues with Selective Fast‐Shrinking Capillaries

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
This study presents a novel 4D bioprinting technique for fabricating cardiac tissues with complex microvasculature. Unlike traditional 3D printing, it enables capillary‐scale structure formation via selective post‐printing shrinkage. This approach overcomes resolution limits of printing cell‐laden hydrogels, allowing the creation of functional ...
Ester Sapir Baruch, Roni Cohen, Eric Silberman, Michael Namestnikov, Itai Cabilly, Assaf Shapira, Tal Dvir   +6 more
wiley   +1 more source

Pancreatic islet composites secrete insulin in response to a glucose challenge [PDF]

, 2017
This study was designed to test the hypothesis that decellularized pancreatic matrices seeded with adult-derived endogenous stem cells and donor islets provide an optimal environment for islets to secrete insulin in response to a glucose challenge. Adult
Black Jr., Asa C, Cope, Lee Anne, Limnios, Jason Ionnis, Lochner, Frank, McCommon, George, Young, Henry E.   +5 more
core   +1 more source

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets [PDF]

, 2009
The function and viability of cultured, transplanted, or encapsulated pancreatic islets is often limited by hypoxia because these islets have lost their vasculature during the isolation process and have to rely on gradient-driven passive diffusion, which
Peter Buchwald, C Ricordi, P Fiorina, SA Nanji, AM Shapiro, PM Galletti, CK Colton, TB Murdoch, T Kin, C Ricordi, S Morini, I Konstantinova, O Cabrera, J Suckale, N Lifson, B Vasir, L Jansson, AS Narang, S Sander, H Ichii, KK Papas, RJ Fleischaker Jr, CA Fraker, ES Avgoustiniatos, WL Robb, V Singh, M Mikola, ES Avgoustiniatos, Y Martin, HK Tilakaratne, JL Dulong, JD Gross, KK Papas, M Radisic, TW Secomb, NM Tsoukias, OC Zienkiewicz, Comsol, AB, KF Riley, DF Wilson, RJ Silbey, JL Dulong, KK Papas, E Avgoustiniatos, IR Sweet, IR Sweet, Comsol, AB, W Hayduk, DM Jenkins, N Bocca, Comsol, AB, JC Hutton, EA Longo, IR Sweet, W Wang, A Despopoulos, T Kaihoh, J Jo, S Merani, RR MacGregor, AE Greijer, AR Hogan, KE Dionne, N Bocca, O Cabrera, FC Schuit   +65 more
core   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin

Stem Cell Research & Therapy, 2019
Background Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation.
Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, Frédéric Lamarche, Cécile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou, Sandrine Lablanche   +12 more
doaj   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

MedComm, Volume 6, Issue 11, November 2025.
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin, Lingxiang Xie, Hongqi Zhang, Xiang Fan, Jiaxing Tian, Wei Liu, Yang Xiao, Xinrong Fan   +7 more
wiley   +1 more source

Isolation, Purification and Characterization of Caprine Pancreatic Islets [PDF]

, 2009
Diabetes mellitus is a major late consequence of chronic pancreatitis. Diabetes mellitus type 1 or insulin-dependent diabetes mellitus (IDDM) is characterized by the failure of the pancreatic islets of Langerhans to synthesis or secrete insulin.
Homayoun Hani,
core  

Human islet transplantation - state of the art [PDF]

Einstein (São Paulo), 2005
Currently, only vascularized pancreas transplantation can reestablishlong-term normoglycemia but the scenario has beenassociated with significant morbidity and mortality.
Eleazar Chaib, Joaquim Gama-Rodrigues, Marcelo Augusto Ribeiro Jr, Willian Abrão Saad, Ivan Cecconello   +4 more
doaj