Results 171 to 180 of about 5,097,355 (300)

Quantifying Differences in the Interferon Signaling Network Across Cell Types [PDF]

, 2019
Griva, Igor, Leviyang, Sivan, Strawn, Nate   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

RNAPaceDB: a dedicated database to dissect RNA velocity across diverse cell types. [PDF]

Nucleic Acids Res
Liu H, Zhou H, Yang S, Ma W, Wang J, Zhang N, Zhang H, Huang W, Zhong X, Xu C, Wang S.   +10 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament. [PDF]

J Bone Joint Surg Am
Garcia SM, Lau J, Wague A, Sharma S, Wang KC, Lizarraga M, Montenegro C, Liu X, O'Connell G, Wong SE, Feeley BT.   +10 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Robust and interpretable prediction of gene markers and cell types from spatial transcriptomics data. [PDF]

Nat Commun
Tan X, Mulay O, Xie J, MacDonald S, Kim T, Zhou C, Xiong Z, Tan SX, Ye N, McCart Reed A, Khosrotehrani K, Roosta F, Trzaskowski M, Simpson PT, Nguyen Q.   +14 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Erratum: A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex

Frontiers in Neuroanatomy, 2019
Frontiers Production Office
doaj   +1 more source

Disentangling associations between complex traits and cell types with seismic. [PDF]

Nat Commun
Lai Q, Dannenfelser R, Roussarie JP, Yao V.   +3 more
europepmc   +1 more source