Results 81 to 90 of about 942,792 (355)

Plant cell wall integrity maintenance in model plants and crop species-relevant cell wall components and underlying guiding principles

Cellular and Molecular Life Sciences, 2019
The walls surrounding the cells of all land-based plants provide mechanical support essential for growth and development as well as protection from adverse environmental conditions like biotic and abiotic stress.
Nora Gigli-Bisceglia, Timo Engelsdorf, Thorsten Hamann   +2 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell Wall Biogenesis Protein Phosphatase CrSsd1 Is Required for Conidiation, Cell Wall Integrity, and Mycoparasitism in Clonostachys rosea [PDF]

Frontiers in Microbiology, 2020
Cell wall biogenesis protein phosphatases play important roles in various cellular processes in fungi. However, their functions in the widely distributed mycoparasitic fungus Clonostachys rosea remain unclear, as do their potential for controlling plant fungal diseases. Herein, the function of cell wall biogenesis protein phosphatase CrSsd1 in C. rosea
Binna Lv, Na Jiang, Rakibul Hasan, Yingying Chen, Manhong Sun, Shidong Li   +5 more
openaire   +3 more sources

The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections

BMC Genomics, 2011
Background Mannoproteins construct the outer cover of the fungal cell wall. The covalently linked cell wall protein Ccw12p is an abundant mannoprotein.
Arroyo Javier, Popolo Laura, García-Cantalejo Jesús, Neupert Christine, Piberger Heidi, Ragni Enrico, Aebi Markus, Strahl Sabine   +7 more
doaj   +1 more source

Cross talk between the Cell Wall Integrity and Cyclic AMP/Protein Kinase A pathways in Cryptococcus neoformans [PDF]

, 2014
Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C.
Donlin, Maureen J, Gerik, Kimberly J, Lam, Woei, Lodge, Jennifer K, Sharma, Neil K, Specht, Charles A, Upadhya, Rajendra, VanArendonk, Laura G   +7 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A core of cell wall proteins functions in wall integrity responses in Arabidopsis thaliana

Plant Direct
Cell walls surround all plant cells, and their composition and structure are tightly regulated to maintain cellular and organismal homeostasis. In response to wall damage, the cell wall integrity (CWI) system is engaged to ameliorate effects on plant ...
Oyeyemi Ajayi, Ellen Zelinsky, Charles T. Anderson   +2 more
doaj   +1 more source

Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly [PDF]

, 2014
The cryptococcal capsule is a critical virulence factor of an important pathogen, but little is known about how it is associated with the cell or released into the environment.
Azadi, Parastoo, Black, Ian, Doering, Tamara L, Heiss, Christian, Kumar, Pardeep, Santiago-Tirado, Felipe H   +5 more
core   +2 more sources

Pectin and phytic acid reduce mineral bioaccessibility in cooked common bean cotyledons regardless of cell wall integrity.

Food Research International, 2020
Common bean cotyledons are rich in minerals (Mg, Ca, Fe and Zn), but they also contain natural barriers that can potentially prevent mineral absorption during digestion.
Sofie Rousseau, Andrea Pallares Pallares, F. Vancoillie, M. Hendrickx, T. Grauwet   +4 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source