Results 121 to 130 of about 9,990 (205)
A computational pipeline to quantify perinuclear lysosomes in fibroblasts using CellProfiler v1
, 2023 Here we present a CellProfiler software pipeline to quantify the distribution of lysosomes in MEF cells. The lysosomes were stained using anti-LAMP1 antibody, and nuclei were labeled using DAPI. The images were acquired using a Zeiss laser scanning confocal microscope and were maximum intensity projected in FIJI.
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Statistics in Medicine, Volume 45, Issue 23-24, October 2026.ABSTRACT Quantitative histology often requires assigning each site or cell to one of two classes from continuous stain intensities. In practice, large‐scale illumination and contrast fluctuations bias thresholds and obscure true biological differences.
Tilman M. Davies
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Autophagy‐gene transcription increases with age and is uncoupled from autophagy flux. Autophagy flux is remodeled sex‐ and cell type‐specifically and is associated with worse physical function in older adults. In a pilot intervention study, elevated PBMC autophagy flux decreased following mild exercise in older adults.
Tatiana M. Moreno +15 more
wiley +1 more source
Advanced Intelligent SystemsHigh‐throughput screening (HTS) can be used when ab initio information is unavailable for rational design of new materials, generating data on properties such as chemistry and topography that control cell behavior.
Robert Owen +10 more
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Aging Cell, Volume 25, Issue 10, October 2026.In contrast to rapid epigenetic de‐aging during induced pluripotent stem cell generation, direct conversion of blood cells into neural stem cells is associated with largely protracted epigenetic de‐aging. The process coincides with prolonged cell fate consolidation, does not require sustained proliferation, and might provide experimental access to ...
Lea Jessica Berg +8 more
wiley +1 more source
Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.Reln haploinsufficiency does not alter fentanyl self‐administration, relapse‐like seeking, or conditioned place preference in mice. Instead, reduced Reln expression selectively enhances acute fentanyl‐induced locomotion and dorsal striatal Fos activation, positioning Reelin as a modulator of opioid‐evoked neuronal activity rather than opioid ...
Carl Litif +6 more
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Modular training resources for bioimage analysis
Journal of Microscopy, Volume 304, Issue 1, Page 3-14, October 2026.Abstract Modern microscopy enables us to measure structural and dynamical properties of many biological processes and is therefore an indispensable research tool. However, the amount and complexity of the produced imaging data is steadily increasing.
Christian Tischer +17 more
wiley +1 more source
Challenging specificity of chemicalcompounds targeting GPCRs with cellprofiling
, 2020 Screening compounds with image-based analysis is an important part in the processof drug discovery. It is an efficient way to screen compounds as it gives moreinformation than for example HTS. High-content screening as it is also called, hasreally progressed in recent years, as the field of data science evolves, and with it sodoes the efficiency of how
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, 2018 Dose response curves of (A) L. infantum or (B) L. amazonensis. IN Cell Investigator Developer Toolbox (red line) and CellProfiler (black line). Values represent the mean and standard deviation of at least two independent experiments.
Ana M. Tomás (199039) +4 more
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The Journal of Physiology, Volume 604, Issue 20, Page 8523-8541, 15 October 2026.Abstract figure legend Skeletal muscle structure was analysed at three levels in young vs. aged humans, and in young vs. aged mice subjected to unilateral hindlimb immobilization to model disuse. (1) Macroscopic: magnetic resonance imaging of the thigh (human) and wet mass of individual hindlimb muscles (mouse) revealed that both ageing and disuse ...
Ramy K. A. Sayed +13 more
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