Results 81 to 90 of about 9,990 (205)

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

open access: yesAdvanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman   +11 more
wiley   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

open access: yesAdvanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri   +28 more
wiley   +1 more source

cellpaintr: Analyze CellProfiler Features in R

open access: yes
High-content imaging can capture detailed morphological and functional features on a single-cell level. It has been widely used in drug screen assays and for generating large-scale image datasets for machine learning models. Software such as CellProfiler extract features from high-content images for downstream analysis.
Laphanuwat, Phatthamon   +2 more
openaire   +1 more source

SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development

open access: yesThe Anatomical Record, EarlyView.
Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli   +6 more
wiley   +1 more source

High-Throughput Method for Automated Colony and Cell Counting by Digital Image Analysis Based on Edge Detection. [PDF]

open access: yesPLoS ONE, 2016
Counting cells and colonies is an integral part of high-throughput screens and quantitative cellular assays. Due to its subjective and time-intensive nature, manual counting has hindered the adoption of cellular assays such as tumor spheroid formation in
Priya Choudhry
doaj   +1 more source

Multiplexed histology reveals phenotypic and spatial characteristics of human Innate Lymphoid Cells in chronic inflammation - CellProfiler Pipelines

open access: yes, 2020
Detailed CellProfiler pipelines for the tonsil and the colon data ...
Pascual-Reguant, Anna (8691852)   +1 more
core   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

open access: yesMovement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin   +10 more
wiley   +1 more source

Muscle2View CellProfiler Supplemental Figure 1

open access: yes, 2019
We provide supplemental files for the manuscipt: "Muscle2View, a CellProfiler pipeline for detection of the capillary-to-muscle fiber interface and high-content quantification of fiber-type specific histology".Supplemental Figure 1Bland-Altman analysis ...
Gema Sanz (7499738)   +4 more
core   +1 more source

omsai/cellgen:

open access: yes, 2022
Generate TIF images for simulating experiment with CellProfiler / CellProfiler ...
Pariksheet Nanda
core   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

open access: yesThe Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot   +17 more
wiley   +1 more source

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