Results 131 to 140 of about 341,348 (303)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Complete developmental cycle of Leishmania mexicana in axenic culture [PDF]

, 1994
A complete developmental sequence of Leishmania mexicana has been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days.
Bates, P A
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Role of epigenetics in developmental biology and transgenerational inheritance

, 2011
The molecular mechanisms involved in developmental biology and cellular differentiation have traditionally been considered to be primarily genetic. Environmental factors that influence early life critical windows of development generally do not have the ...
Michael K. Skinner, Skinner, Michael K
core   +2 more sources

Mortality, developmental biology and cellular immunity in achroia grisella (Fabricius, 1794) (Lepidoptera: Pyralidae) larvae exposed to azadirachtin

, 2022
Azadirachtin, obtained from neem trees, can be a robust alternative to synthetic pesticides for the control of agricultural pests with no resistance problems. Azadirachtin-induced influences on mortality, life history traits and cellular immunity indicators of the lesser wax moth Achroia grisella (Fabricius, 1794) (Lepidoptera: Pyralidae) were ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1

, 2015
Kinesins are a superfamily of microtubule-based molecular motors that perform various transport needs and have essential roles in cell division. Among these, the kinesin-5 family has been shown to play a major role in the formation and maintenance of the
Maia, André F, Medema, René H, Sub Developmental Biology, Gassmann, Reto, van den Heuvel, Sander, Egan, David A, Galli, Matilde, Dep Biologie, Developmental Biology, Tanenbaum, Marvin E, Lelieveld, Daphne, Sunkel, Claudio E   +11 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Genetic perspectives on the ascidian central nervous system

Invertebrate Survival Journal, 2009
In 2002, date of publication of the Ciona intestinalis genome, ascidians entered the post-genomic era. This tool had a fundamental role and has become the starting point for a series of new functional and genomic studies.
A Locascio, F Ristoratore, A Spagnuolo, L Zanetti, M Branno   +4 more
doaj  

Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens

Scientific Reports
Oxytocin (Oxtr) and dopamine (Drd1, Drd2) receptors provide a canonical example for how differences in neuromodulatory receptors drive individual and species-level behavioral variation. These systems exhibit striking and functionally relevant differences
Meredith K. Loth, Julia C. Schmidt, Cassandra A. Gonzalez, Liza E. Brusman, Julie M. Sadino, Kelly E. Winther, David S. W. Protter, Zoe R. Donaldson   +7 more
doaj   +1 more source