Results 31 to 40 of about 365,586 (305)

HyperNCA: Growing Developmental Networks with Neural Cellular Automata [PDF]

, 2022
In contrast to deep reinforcement learning agents, biological neural networks are grown through a self-organized developmental process. Here we propose a new hypernetwork approach to grow artificial neural networks based on neural cellular automata (NCA).
Sudhakaran, Shyam, Glanois, Claire, Risi, Sebastian, Najarro, Elias; id_orcid   +3 more
core   +3 more sources

Synthetic cargo adaptors reveal molecular features that enhance dynein activation

Nature Communications
Cytoplasmic dynein-1 (dynein) facilitates the microtubule-based retrograde trafficking of all cellular cargo. To become active, dynein binds dynactin and one of many cargo-specific adaptors forming the dynein-dynactin-adaptor transport complex.
Aravintha Siva, John P. Gillies, Ashley de Borchgrave, Sharon R. Garrott, Rishi Mishra, Rita El Jbeily, Reagan S. Clarke, Cameron Conklin, Daytan Gibson, Juliana L. Zang, Morgan E. DeSantis   +10 more
doaj   +1 more source

Spatial self-organization resolves conflicts between individuality and collective migration

Nature Communications, 2018
How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient ...
X. Fu, S. Kato, J. Long, H. H. Mattingly, C. He, D. C. Vural, S. W. Zucker, T. Emonet   +7 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

The Philosophy of Molecular and Developmental Biology [PDF]

, 2000
Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction.
Griffiths, Paul Edmund
core  

Dictionary of Developmental Biology and Embryology, 2nd edition

, 2012
Developmental biology is the study of the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels.
Dye, Frank
core   +2 more sources

The poly-proline motifs found in the cytoplasmic tail of the brush border cadherin CDHR5 play a role in its ability to elongate microvilli

microPublication Biology
Cadherin-related family member 5 (CDHR5) is a protocadherin found enriched at the tips of brush border microvilli of the gut and kidney, where it plays an important role in the development of these specialized microvilli.
Samaneh Matoo, Prashun Acharya, Sadika T.J. Tonu, Jasvinder Bharaj, Ashwini Mudaliyar, Basmala Touny, Regan VanderPol, Morgan Timms, Nicole Dyko, Domtie Asante, Hawa Abdulle, Scott W. Crawley   +11 more
doaj   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

eLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon, Dipjyoti Das, Dörthe Jülich, Abdel-Rahman Hassan, Hannah Geller, Scott Holley   +5 more
doaj   +1 more source

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

Nature Communications, 2023
Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing.
Tolga T. Ölmez, David F. Moreno, Ping Liu, Zane M. Johnson, Madeline M. McGinnis, Benjamin P. Tu, Mark Hochstrasser, Murat Acar   +7 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source