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Systems Biology and the Integration of Mechanistic Explanation and Mathematical Explanation [PDF]

, 2013
The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation.
Brigandt, Ingo
core   +1 more source

Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system

Communications Biology, 2022
The current state and limitations of research on extracellular vesicles in central nervous system (CNS) signaling are discussed, with particular focus on EV-mediated cargo transfer.
Chun Wan, Michael H. B. Stowell, Jingshi Shen   +2 more
doaj   +1 more source

Spatial self-organization resolves conflicts between individuality and collective migration

Nature Communications, 2018
How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient ...
X. Fu, S. Kato, J. Long, H. H. Mattingly, C. He, D. C. Vural, S. W. Zucker, T. Emonet   +7 more
doaj   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

eLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon, Dipjyoti Das, Dörthe Jülich, Abdel-Rahman Hassan, Hannah Geller, Scott Holley   +5 more
doaj   +1 more source

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

Nature Communications, 2023
Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing.
Tolga T. Ölmez, David F. Moreno, Ping Liu, Zane M. Johnson, Madeline M. McGinnis, Benjamin P. Tu, Mark Hochstrasser, Murat Acar   +7 more
doaj   +1 more source

Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition

, 2020
Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL).
Lyakisheva, Anna, Boxem, Mike, Jurisica, Igor, Kotlyar, Max, Tang, Priscilla, Sub Developmental Biology, Aboualizadeh, Farzaneh, Akula, Indira, Yao, Zhong, Stagljar, Igor, Kroll, Jason, Snider, Jamie, Developmental Biology   +12 more
core   +1 more source

An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus

Plant Methods
CRISPR/Cas9-mediated gene editing requires high efficiency to be routinely implemented, especially in species which are laborious and slow to transform. This requirement intensifies further when targeting multiple genes simultaneously, which is required ...
Cintia H. D. Sagawa, Geoffrey Thomson, Benoit Mermaz, Corina Vernon, Siqi Liu, Yannick Jacob, Vivian F. Irish   +6 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

The Philosophy of Molecular and Developmental Biology [PDF]

, 2000
Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction.
Griffiths, Paul Edmund
core  

TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling

Cell Reports, 2017
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude. Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vascular β-catenin signaling in ...
Maria B. Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W. Klymkowsky, Zhe Chen, Harald J. Junge   +8 more
doaj   +1 more source