Results 121 to 130 of about 358,177 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration

Journal of Neuroinflammation
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (PD), with microglia playing a central role in mediating neuroinflammatory signaling in the brain.
Henry Kurniawan, Sarah L. Nickels, Alise Zagare, Elisa Zuccoli, Isabel Rosety, Gemma Gomez-Giro, Enrico Glaab, Jens C. Schwamborn   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Epithelial polarity and growth signaling by Drosophila tumor suppressor genes [PDF]

, 2018
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tumor suppressor genes in fruit flies have provided major insights towards polarity and growth signaling, while also aiding the understanding of complex ...
Vreede, G., Sub Developmental Biology
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Breakthroughs and challenges of modern developmental biology and reproductive medicine

, 2019
In recent decades we have witnessed unprecedented progress in the field of the developmental biology of mammals. Building on 20 th century discoveries, we have managed to increase our understanding of the molecular and cellular mechanisms governing ...
Fishel, Simon, Ajduk, Anna, Plusa, Berenika, Yamanaka, Yojiro, Hadjantonakis, Anna Katerina, Rienzi, Laura, Suwińska, Aneta, Hadjantonakis, Anna-Katerina   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evolutionarily conserved crosstalk in developmental biology

Cellular communication is a fundamental process in animal development and homeostasis. Signaling pathways are the basis of this communication, as the transduction of external and internal cues leads to a cellular response such as cell migration, division
Sub Developmental Biology, Mars, Jonas Daniël, Korswagen, Hendrik, Galli, Matilde, Developmental Biology   +4 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation

Nature Communications
Copy number variation (CNV) plays a fundamental role in modulating plant agronomic traits and tumorigenesis in animals. While frequently linked to replication stress, the mechanisms giving rise to CNVs are not fully elucidated.
Geoffrey Thomson, Axel Poulet, Yi-Chun Huang, Hong-Sheng Liao, Chantal LeBlanc, Yannick Jacob   +5 more
doaj   +1 more source