Results 231 to 240 of about 216,120 (296)

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

The Influence of Extracellular Citrate in Physiological Concentration on the Proliferation of Malignant Melanoma. [PDF]

J Cell Mol Med
Drexler K, Schwertner B, Zenderowski V, Schreieder L, Harrer DC, Berneburg M, Geissler E, Mycielska M, Haferkamp S.   +8 more
europepmc   +1 more source

An Increasing Misalignment Between Crop Distribution and Environmental Resources Under Climate Change in China

Advanced Science, EarlyView.
Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su, Zhentao Zhang, Jin Zhao, Xia Liang, Chuang Zhao, Zhijuan Liu, Minghao Zhuang, Jing Sun, Bo Lu, Ke Liu, Johannes W. M. Pullens, Matthew T. Harrison, Deli Chen, Xiaoguang Yang   +13 more
wiley   +1 more source

Next-generation Alzheimer's therapeutics: target assessment and enablement at the Indiana University School of Medicine-Purdue University TREAT-AD Center. [PDF]

Alzheimers Dement
Richardson TI, Klein RC, Huang K, Zhang J, Mesecar AD, Dage JL, Clayton B, Lamb BT, Palkowitz AD.   +8 more
europepmc   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

PHLDA1 silencing in IMR-32 human neuroblastoma cells results in ABCB1 overexpression, augments chemoresistance and leads to increased growth of tumors. [PDF]

Sci Rep
Kudrycka M, Horwacik I, Brożyna AA, Żywicka M, Durbas M, Rokita H.   +5 more
europepmc   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Immunoinformatic-driven design of a multi-epitope vaccine against <i>Helicobacter</i> <i>pylori</i>. [PDF]

Biochem Biophys Rep
Rahimi-Farsi N, Bostanian F, Ahmadi K, Zangooie A, Sedighi M, Shahbazi B, Mottaghi-Dastjerdi N.   +6 more
europepmc   +1 more source