Results 231 to 240 of about 1,916,376 (328)

Next-generation Alzheimer's therapeutics: target assessment and enablement at the Indiana University School of Medicine-Purdue University TREAT-AD Center. [PDF]

Alzheimers Dement
Richardson TI, Klein RC, Huang K, Zhang J, Mesecar AD, Dage JL, Clayton B, Lamb BT, Palkowitz AD.   +8 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

All-in-One Method for Iterative Single-Cell Dielectrophoretic and Optical Characterization: Advancing the OpenDEP Platform

ACS Omega
Florela Gherghinoiu, Tudor Savopol, Ioan Tivig, Mihaela G. Moisescu   +3 more
doaj   +1 more source

Liraglutide Modulates Zinc Release and Improves Mitochondrial Function in Insulin-Resistant Senescent Cardiomyocytes. [PDF]

Cardiovasc Toxicol
Hosseinpourshirazi F, Mendes UD, Aksoy ZB, Aydos D, Sözer M, Aljaser L, Gundogdu M, Sık S, Tuncay E, Turan B, Olgar Y.   +10 more
europepmc   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

PHLDA1 silencing in IMR-32 human neuroblastoma cells results in ABCB1 overexpression, augments chemoresistance and leads to increased growth of tumors. [PDF]

Sci Rep
Kudrycka M, Horwacik I, Brożyna AA, Żywicka M, Durbas M, Rokita H.   +5 more
europepmc   +1 more source

vEMINR: Ultra‐Fast Isotropic Reconstruction for Volume Electron Microscopy With Implicit Neural Representation

Advanced Science, EarlyView.
vEMINR is an ultra‐fast isotropic reconstruction method for vEM based on implicit neural representation, achieving over tenfold faster reconstruction and higher accuracy on 11 datasets, showing strong potential for large‐scale vEM data processing.
Jibin Yang, Jie Huo, Muyu Liu, Chenjie Feng, Yan Zhang, Gang Pan, Wenjia Meng, Renmin Han   +7 more
wiley   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. [PDF]

Angew Chem Int Ed Engl
Schäfer D, Prieto-Garcia C, Wang J, Heinz M, Matkovic V, Kielkowski P, Hasselbeck S, Shah VJ, Knapp S, Hummer G, Dikic I, Cheng X.   +11 more
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Correction: Chukavin et al. Redox-Active Cerium Fluoride Nanoparticles Selectively Modulate Cellular Response against X-ray Irradiation In Vitro. <i>Biomedicines</i> 2024, <i>12</i>, 11. [PDF]

Biomedicines
Chukavin NN, Filippova KO, Ermakov AM, Karmanova EE, Popova NR, Anikina VA, Ivanova OS, Ivanov VK, Popov AL.   +8 more
europepmc   +1 more source