Results 1 to 10 of about 1,611,391 (358)

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]

, 2016
A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad, Friedman, Michael, Graeber, Thomas G, Hong, Aayoung, Hugo, Willy, Komisopoulou, Evangelia, Kong, Xiangju, Le, Allison, Li, Richard, Lo, Roger S, Lomova, Anastasia, Moriceau, Gatien, Ribas, Antoni, Shi, Hubing, Song, Chunying, Ten Hoeve, Johanna, Titz, Bjoern   +16 more
core   +3 more sources

Fungal Elicitation Enhances Vincristine and Vinblastine Yield in the Embryogenic Tissues of Catharanthus roseus

Plants, 2023
Fungal elicitation could improve the secondary metabolite contents of in vitro cultures. Herein, we report the effect of Fusarium oxysporum on vinblastine and vincristine alkaloid yields in Catharanthus roseus embryos. The study revealed increased yields
Dipti Tonk, Abdul Mujib, Mehpara Maqsood, Mir Khusrau, Ali Alsughayyir, Yaser Hassan Dewir   +5 more
doaj   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

Avalanche of Bifurcations and Hysteresis in a Model of Cellular Differentiation

, 1999
Cellular differentiation in a developping organism is studied via a discrete bistable reaction-diffusion model. A system of undifferentiated cells is allowed to receive an inductive signal emenating from its environment.
A. J. Koch, A. Turing, B. Zinner, B. Zinner, D. F. Ready, D. G. Aronson, G. Fáth, J. P. Keener, J. P. Keener, J. P. Laplante, J. Rinzel, K. Basler, M-A. Felix, P. C. Bressloff, P. C. Fife, P. W. Sternberg, S. A. Kauffman, S. F. Gilbert, T. Erneux, T. Sobrino, U. Heberlein   +20 more
core   +1 more source

The effects of growth factors on multicellular spheroids formed by chick embryonic retinal cells [PDF]

, 1997
Retinal cells from chick embryos aged 7.5 days of gestation were cultured for two months in a non-adherent suspension culture dish to study the effects of growth factors and co-culture with retinal pigment epithelial cells on their differentiation ...
Matsuo, Nobuhiko, Matsuo, Toshihiko, Takabatake, Mayumi   +2 more
core   +1 more source

Tissue-Specific Natural Synthesis of Galanthaminein Zephyranthes Species and Its Accumulation in Different In Vitro-Grown Organs Following Methyl Jasmonate Treatment

Plants
Galanthamine is an immensely valuable alkaloid exhibiting anti-cancer and antiviral activity. The cultivation of plant tissues in in vitro conditions is a good source for the synthesis and enrichment of secondary metabolites of commercial interest.
Rukaya Syeed, A. Mujib, Yashika Bansal, Mohammad Mohsin, Afeefa Nafees, Moien Qadir Malik, Jyoti Mamgain, Bushra Ejaz, Yaser Hassan Dewir, Katalin Magyar-Tábori   +9 more
doaj   +1 more source

Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia

Molecular Genetics and Metabolism Reports, 2015
Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) activity.
Young Mok Lee, Goo-Young Kim, Chi-Jiunn Pan, Brian C. Mansfield, Janice Y. Chou   +4 more
doaj   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Comparative Transcriptome Analysis of Non-Organogenic and Organogenic Tissues of Gaillardia pulchella Revealing Genes Regulating De Novo Shoot Organogenesis

Horticulturae
Gaillardia pulchella is an important plant species with pharmacological and ornamental applications. It contains a wide array of phytocompounds which play roles against diseases.
Yashika Bansal, A. Mujib, Mahima Bansal, Mohammad Mohsin, Afeefa Nafees, Yaser Hassan Dewir   +5 more
doaj   +1 more source

Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L

Frontiers in Plant Science
Digitalis purpurea L. is one of the important plant species of Nilgiris, Kashmir and Darjeeling regions of India, belonging to the family Plantaginaceae, with well-known pharmacological applications.
Yashika Bansal, A. Mujib, Jyoti Mamgain, Rukaya Syeed, Mohammad Mohsin, Afeefa Nafees, Yaser Hassan Dewir, Nóra Mendler-Drienyovszki   +7 more
doaj   +1 more source