Results 191 to 200 of about 1,589,246 (309)

Control of Cellular Differentiation Trajectories for Cancer Reversion. [PDF]

Adv Sci (Weinh)
Gong JR, Lee CK, Kim HM, Kim J, Jeon J, Park S, Cho KH.   +6 more
europepmc   +1 more source

Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp. [PDF]

Mol Cell Proteomics, 2022
Xu C, Wang B, Heng H, Huang J, Wan C.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Plasticity and the evolution of group-level regulation of cellular differentiation in the volvocine algae. [PDF]

Proc Biol Sci
Davison DR, Nedelcu AM, Eneji OA, Michod RE.   +3 more
europepmc   +1 more source

Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. [PDF]

Nat Commun, 2023
Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T.   +13 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense. [PDF]

Nat Commun, 2022
Horáková E, Lecordier L, Cunha P, Sobotka R, Changmai P, Langedijk CJM, Abbeele JVD, Vanhollebeke B, Lukeš J.   +8 more
europepmc   +1 more source

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

, 2008
Gregory David, Kathryn B. Grandinetti, Patricia M. Finnerty, Natalie E. Simpson, Gerald C. Chu, Ronald A. DePinho   +5 more
openalex   +1 more source

Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma [PDF]

, 2013
Wenqi Wang, Quan Zhong, Lisong Teng, Namrata Bhatnagar, Bhuvanesh Kumar Sharma, Xin Zhang, William Luther, Lee P. Haynes, Robert D. Burgoyne, Marc Vidal, Samuel L. Volchenboum, David E. Hill, Richard E. George   +12 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source