Results 211 to 220 of about 607,739 (256)
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Maintaining differentiated cellular identity
Nature Reviews Genetics, 2012Various studies have demonstrated that somatic differentiated cells can be reprogrammed into other differentiated states or into pluripotency, thus showing that the differentiated cellular state is not irreversible. These findings have generated intense interest in the process of reprogramming and in mechanisms that govern the pluripotent state ...
Johan, Holmberg, Thomas, Perlmann
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Cellular Models of Trophoblast Differentiation
Seminars in Reproductive Medicine, 2016Orchestrated trophoblast differentiation is necessary to establish and maintain a normal pregnancy, however the molecular mechanisms that guide this process remain largely unknown. Although early studies of cytotrophoblast differentiation relied on animal models, more recent trophoblast research has involved in vitro models of human tissue.
Marissa L, Steinberg, Jared C, Robins
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Cellular neurothekeoma with histiocytic differentiation
Journal of Cutaneous Pathology, 2004Background: It is generally accepted that the two types of neurothekeoma (myxoid type and cellular type) represent the two poles of a spectrum. This concept, however, has recently been challenged, and cellular neurothekeomas have been suggested as a separate classification and are included in the ‘fibrohistiocytic’ category by some authors.
Noriyuki, Misago +2 more
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International journal of obesity, 1986
Substantial evidence now points to DNA methylation playing a primary role in locking genes in the "off' condition. Specific hypomethylation events may be necessary but not sufficient for gene expression. 5-azacytidine is a useful drug to perturb DNA methylation patterns and determine the effects of these perturbations on gene expression.
S M, Taylor, P A, Jones
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Substantial evidence now points to DNA methylation playing a primary role in locking genes in the "off' condition. Specific hypomethylation events may be necessary but not sufficient for gene expression. 5-azacytidine is a useful drug to perturb DNA methylation patterns and determine the effects of these perturbations on gene expression.
S M, Taylor, P A, Jones
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Hypoxia, pseudohypoxia and cellular differentiation
Experimental Cell Research, 2017Tumor hypoxia correlates to aggressive disease, and while this is explained by a variety of factors, one clue to understand this phenomena was the finding that hypoxia induces a de-differentiated, stem cell-like phenotype in neuroblastoma and breast tumor cells. The hypoxia inducible transcription factors (HIFs) are regulated at the translational level
Sofie, Mohlin +3 more
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Mitochondrial biogenesis during cellular differentiation
American Journal of Physiology-Cell Physiology, 1997Mitochondrial biogenesis was studied during differentiation of two immortalized cell lines (C2C12, 3T3) with enzyme measurements, Northern blots, and quantitative ultrastructure. Citrate synthase, isocitrate dehydrogenase, and 3-hydroxyacyl-CoA dehydrogenase (nuclear encoded, mitochondrial matrix location) showed linear, four- to sixfold increases in ...
C D, Moyes +4 more
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Differentiation, oncogenesis and cellular periodicities
Journal of Theoretical Biology, 1968Abstract An outline is given of a concept of differentiation and oncogenesis which is based on the existence of cellular biochemical periodicities. It is proposed that the properties of a cell are largely determined by the pattern of rhythmic variations in constituent levels resulting from the operation of numerous metabolic control circuits.
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TUMOURS, HORMONES, AND CELLULAR DIFFERENTIATION
The Lancet, 1969Abstract The " ectopic " production of hormones by tumours is set in the wider context of structural and functional metaplasia and considered in relation to the control of cell structure and function by D.N.A. The association of hormone production with certain specific tumour types and not with others, best shown for corticotrophin, is not consistent
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Understanding Cellular Differentiation
2010Developmental biology is making tremendous progress in describing the mechanisms that coordinate developmental programs and lead to the specification and differentiation of the correct cell at the correct position with appropriate synaptic or cell–cell contacts.
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