Results 201 to 210 of about 1,468,423 (351)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

A segmentation clock patterns cellular differentiation in a bacterial biofilm. [PDF]

Cell, 2022
Chou KT, Lee DD, Chiou JG, Galera-Laporta L, Ly S, Garcia-Ojalvo J, Süel GM.   +6 more
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. [PDF]

Nat Commun, 2023
Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T.   +13 more
europepmc   +1 more source

Thymic control of cellular differentiation in the immunological system

, 1968
David Osoba
openalex   +1 more source

Cellular differentiation in the emerging fetal rat small intestinal epithelium: mosaic patterns of gene expression. [PDF]

, 1989
Deborah C. Rubin, D E Ong, J I Gordon
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Nuclear envelope and chromatin choreography direct cellular differentiation. [PDF]

Nucleus
Nair A, Khanna J, Kler J, Ragesh R, Sengupta K.   +4 more
europepmc   +1 more source

Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp. [PDF]

Mol Cell Proteomics, 2022
Xu C, Wang B, Heng H, Huang J, Wan C.
europepmc   +1 more source

Photosynthetic Gene Expression and Cellular Differentiation in Developing Maize Leaves [PDF]

, 1985
Belinda Martineau, William C. Taylor
openalex   +1 more source