Results 201 to 210 of about 4,342,740 (357)

Integrated single-cell transcriptomics and spatial metabolomics unveil cellular differentiation and ginsenosides biosynthesis in <i>Panax</i> root tips. [PDF]

Hortic Res
Yang L, Yang Z, Liu M, Wang S, Wu H, Yang Q, Huang L, Yang Y, Cui X, Liu Y.   +9 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Non-Antibacterial Effects of Azithromycin and Other Macrolides on the Bronchial Epithelial Barrier and Cellular Differentiation. [PDF]

Int J Mol Sci
Asbjarnarson A, Joelsson JP, Gardarsson FR, Sigurdsson S, Parnham MJ, Kricker JA, Gudjonsson T.   +6 more
europepmc   +1 more source

Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation [PDF]

, 2007
Flávia Regina Souza Lima, C Arantes, Angelita Muras, Regina Nomizo, Helena Brentani, Vilma R. Martins   +5 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Defining the role of 2,2',4,4'-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis. [PDF]

Adipocyte
Liu ZL, Qiayimaerdan A, Fan Y, Jiang SR, Tuerxuna Z, Wang ML, Abudureheman H.   +6 more
europepmc   +1 more source

High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype. [PDF]

Mol Cell Proteomics, 2022
Wang D, Wang D, Madunić K, Zhang T, Mayboroda OA, Lageveen-Kammeijer GSM, Wuhrer M.   +6 more
europepmc   +1 more source

Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation.

Einstein Journal of Biology and Medicine, 2016
Ying Yang, A. Cvekl
semanticscholar   +1 more source

Additional file 2: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds

, 2015
Magali SanCristobal, Florian Rohart, Christine Lascor, Marcel Bouffaud, Lidwine Trouilh, Pascal G.P. Martin, Yannick Lippi, Thierry Tribout, Thomas Faraut, M. J. Mercat, Denis Milan, Laurence Liaubet   +11 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source