Results 71 to 80 of about 4,741,341 (392)

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Comparative Transcriptome Analysis of Non-Organogenic and Organogenic Tissues of Gaillardia pulchella Revealing Genes Regulating De Novo Shoot Organogenesis

Horticulturae
Gaillardia pulchella is an important plant species with pharmacological and ornamental applications. It contains a wide array of phytocompounds which play roles against diseases.
Yashika Bansal, A. Mujib, Mahima Bansal, Mohammad Mohsin, Afeefa Nafees, Yaser Hassan Dewir   +5 more
doaj   +1 more source

Avalanche of Bifurcations and Hysteresis in a Model of Cellular Differentiation

, 1999
Cellular differentiation in a developping organism is studied via a discrete bistable reaction-diffusion model. A system of undifferentiated cells is allowed to receive an inductive signal emenating from its environment.
A. J. Koch, A. Turing, B. Zinner, B. Zinner, D. F. Ready, D. G. Aronson, G. Fáth, J. P. Keener, J. P. Keener, J. P. Laplante, J. Rinzel, K. Basler, M-A. Felix, P. C. Bressloff, P. C. Fife, P. W. Sternberg, S. A. Kauffman, S. F. Gilbert, T. Erneux, T. Sobrino, U. Heberlein   +20 more
core   +1 more source

Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface [PDF]

, 2018
Respiratory tract infections are of significant concern in the agriculture industry. There is a requirement for the development of well-characterised in vitro epithelial cell culture models in order to dissect the diverse molecular interactions occurring
Berry, Catherine C., Davies, Robert L., O'Boyle, Nicky, Sutherland, Erin   +3 more
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The Calcium-Sensing Receptor and Integrins in Cellular Differentiation and Migration

Frontiers in Physiology, 2016
The calcium-sensing receptor (CaSR) is a widely expressed homodimeric G-protein coupled receptor structurally related to the metabotropic glutamate receptors and GPRC6A.
S. Tharmalingam, D. Hampson
semanticscholar   +1 more source

Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L

Frontiers in Plant Science
Digitalis purpurea L. is one of the important plant species of Nilgiris, Kashmir and Darjeeling regions of India, belonging to the family Plantaginaceae, with well-known pharmacological applications.
Yashika Bansal, A. Mujib, Jyoti Mamgain, Rukaya Syeed, Mohammad Mohsin, Afeefa Nafees, Yaser Hassan Dewir, Nóra Mendler-Drienyovszki   +7 more
doaj   +1 more source

In vivo detection of lamellocytes in Drosophila melanogaster. [PDF]

, 2009
Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific ...
Brand, Braun, Carton, Evans, Evans, Goto, Hartenstein, Hoffmann, Hultmark, Konrad, Kurucz, Kurucz, Kurucz, Lanot, Metaxakis, Márkus, Márkus, Zettervall   +17 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source