Results 71 to 80 of about 1,459,173 (350)

Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases

Frontiers in Endocrinology, 2020
Octadecaneuropeptide (ODN) and its precursor diazepam-binding inhibitor (DBI) are peptides belonging to the family of endozepines. Endozepines are exclusively produced by astroglial cells in the central nervous system of mammals, and their release is ...
Olfa Masmoudi-Kouki, Amira Namsi, Amira Namsi, Yosra Hamdi, Seyma Bahdoudi, Seyma Bahdoudi, Ikram Ghouili, Julien Chuquet, Jérôme Leprince, Jérôme Leprince, Benjamin Lefranc, Benjamin Lefranc, Taoufik Ghrairi, Marie-Christine Tonon, Gérard Lizard, David Vaudry, David Vaudry   +16 more
doaj   +1 more source

Retinoblastoma Protein Paralogs and Tumor Suppression

Frontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +1 more source

Patterns of cell movement within the Dictyostelium slug revealed by cell type-specific, surface labeling of living cells [PDF]

, 1994
There are cells acattered in the rear, prespore region of the Dictyostelium slug that share many of the properties of the prestalk cells and that are therefore called anterior-like cells (ALCs).
Akiyama, Blaschke, Bonner, Bonner, Buhl, Ceccarelli, Chung, Devine, Early, Early, Early, Evan, Francis, Gaskell, Gregg, Gregg, Hadwiger, Harlow, Harwood, Howard, Jermyn, Jermyn, Kakutani, McRobbie, Montell, Niehrs, Nomura, Raper, Raper, Rubin, Salser, Siegert, Siegert, Siegert, Steinbock, Sternfeld, Sternfeld, Sternfeld, Takeuchi, Ti, Watts, Williams   +41 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift

Gut Microbes
The majority of cohort-specific studies associating gut microbiota with obesity are often contradictory; thus, the replicability of the signature remains questionable.
Deep Chanda, Debojyoti De
doaj   +1 more source

Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

Frontiers in Cell and Developmental Biology, 2018
Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two ...
Jana Oltova, Ondrej Svoboda, Ondrej Svoboda, Petr Bartunek   +3 more
doaj   +1 more source

Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]

, 2015
Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin, Gadegaard, Nikolaj, Hansson, Mattias, Holzmann Rasmussen, Camilla, McMeeking, Robert M., Petersen, Dorthe Roenn, Reynolds, Paul   +6 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Chromatin conformation signatures of cellular differentiation [PDF]

Genome Biology, 2009
AbstractOne of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation signatures with 5C technology http://Dostielab.
Mathieu Rousseau, Mathieu Blanchette, Josée Dostie, Solomon Shenker, Maria Ferraiuolo, Yoshihide Hayashizaki, James Fraser   +6 more
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source