Results 61 to 70 of about 6,415,449 (238)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Nuclear Energy and Technology, 2017 Reactors with heavy water coolants and moderators have been used extensively in today's power industry. Monitoring of the moderator condition plays an important role in ensuring normal operation of a power plant.
S.O. Starkov, Y.N. Lavrenkov
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cellular tagging as a neural network mechanism for behavioural tagging
Nature Communications, 2016 Short-term memories (STM) can become long-term memories when occurring alongside novel experiences. Here, the authors investigate the neural mechanisms behind such 'behavioural tagging' and find STM neural populations are preferentially incorporated into
Masanori Nomoto +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Cellular Neural Network with Time Sequential Input [PDF]
, 1998 A cellular neura1 network with nesequentia1 input is investigated. In our model, Hebb rule is used as an unsupervised learning ru1e. With respect to learning rate C and slope of sigmoid functionε, four phases are observed,i. e.,ordering state. disordered
工藤, 清 +7 more
core
Recurrent Neural Network Based Narrowband Channel Prediction
, 2006 In this contribution, the application of fully connected recurrent neural networks (FCRNNs) is investigated in the context of narrowband channel prediction.
Liu, W., Yang, L-L., Hanzo, L.
core +1 more source
In–Ga–Zn–O Thin-Film Devices As Synapse Elements in a Neural Network
IEEE Journal of the Electron Devices Society, 2018 We have succeeded in utilizing In-Ga-Zn-O (IGZO) thin-film devices as synapse elements in a neural network. The electrical conductance is regarded as the connection strength, and the continuous change by flowing electrical current is employed as the ...
Mutsumi Kimura +5 more
doaj +1 more source