Results 191 to 200 of about 233,840 (301)

Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction. [PDF]

Circulation
Bann GG, Dos Santos M, Chen K, Tan W, Bezprozvannaya S, Gan P, Xu L, Liu N, Bassel-Duby R, Olson EN.   +9 more
europepmc   +1 more source

Nonmuscle myosin IIB is a driver of cellular reprogramming. [PDF]

Mol Biol Cell, 2023
Balaban AE, Nguyen LTS, Parajón E, Robinson DN.   +3 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration. [PDF]

Cell Rep, 2023
Salinas-Saavedra M, Febrimarsa, Krasovec G, Horkan HR, Baxevanis AD, Frank U.   +5 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics. [PDF]

J Transl Med
Hosseini ST, AminianToosi K, Nemati F, BishehKolaei R, Deng Y.   +4 more
europepmc   +1 more source

Cyclic Stretch Promotes Cellular Reprogramming Process through Cytoskeletal-Nuclear Mechano-Coupling and Epigenetic Modification. [PDF]

Adv Sci (Weinh), 2023
Park SM, Lee JH, Ahn KS, Shim HW, Yoon JY, Hyun J, Lee JH, Jang S, Yoo KH, Jang YK, Kim TJ, Kim HK, Lee MR, Jang JH, Shim H, Kim HW.   +15 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Interleukin-4-mediated Pro-Regenerative Cellular Reprogramming in 3-dimensional Liver Culture. [PDF]

Cell Mol Gastroenterol Hepatol
Camat D, Nakib D, Chung SW, Sekhon M, Liu Y, Lumanto P, Hyduk SJ, Perciani CT, Bartczak AM, Cheng ML, Pezzutti OI, Kaltagian M, Altaf F, Jafari SM, Manuel J, Thoeni C, Ogawa S, Ma XZ, McGilvray ID, MacParland SA.   +19 more
europepmc   +1 more source

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature. [PDF]

Sci Rep, 2023
Horisawa K, Miura S, Araki H, Miura F, Ito T, Suzuki A.   +5 more
europepmc   +1 more source