Results 191 to 200 of about 1,403,431 (298)

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Correction: Engineering extracellular vesicles for ROS scavenging and tissue regeneration

Nano Convergence
Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim   +6 more
doaj   +1 more source

Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis. [PDF]

Exp Mol Med
Liu YW, Zou JT, Gong JS, Jin L, Cao J, He ZH, Qian YX, Wang X, Wan MD, Hu XY, Hong CG, Du W, Chen CY, Liu HJ, Xie H, Wang ZX.   +15 more
europepmc   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

From Stress to Survival: Trophoblast-Derived Extracellular Vesicle Proteome Captures Aspirin-Driven Cellular Reprogramming in a Preeclampsia Model. [PDF]

Pharmaceutics
Mahajan V, Kumar A, Jacob J, Costantine MM, Richardson LS, Urrabaz-Garza R, Amabebe E, Tantengco OAG, Kammala AK, Menon R.   +9 more
europepmc   +1 more source

Reprogramming Stars #11 Teaming Up to Uncover the Epitranscriptomics of Reprogramming - An Interview with Dr. Miguel Fidalgo and Dr. Diana Guallar

, 2023
Pereira, Carlos Filipe,, Guallar, Diana,, Lund University., Fidalgo, Miguel,   +3 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Proteomic Signatures of Cellular Reprogramming in Bladder Cancer: Insights into the Acquisition of Cancer Stem-like States and Phenotypic Plasticity. [PDF]

Cancer Genomics Proteomics
Barlak BSR, Iskender B.
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Rethinking Oxidative Stress in <i>Helicobacter pylori</i>: A Multidisciplinary Framework Linking Redox Signaling, Cellular Reprogramming, and Diagnostic Precision in Gastric Carcinogenesis. [PDF]

Life (Basel)
Elbehiry A, Abalkhail A, Anagreyyah S, Anjiria S, Aljahdali M, Alharbi M, Almutairi N, Althagafi M, Edrees HM, Almuzaini AM, Moussa IM, Alhamyani S, Almaliki A, Marzouk E.   +13 more
europepmc   +1 more source