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Texas Heart Institute journal, 2014 Some of the next articles are maybe not open access.
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The Ethics of Cellular Reprogramming
Cellular Reprogramming, 2023Louise Brown's birth in 1978 heralded a new era not just in reproductive technology, but in the relationship between science, cells, and society. For the first time, human embryos could be created, selected, studied, manipulated, frozen, altered, or destroyed, outside the human body. But with this possibility came a plethora of ethical questions. Is it
Anna Smajdor, Adrian Villalba
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SOX17 in cellular reprogramming and cancer
Seminars in Cancer Biology, 2020SOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the cardiovascular system and several endoderm-derived organs. The analysis of cancer genome sequencing data classified SOX17 as mutated cancer driver gene in endometrial ...
Daisylyn Senna, Tan +4 more
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2006
The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
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The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
openaire +2 more sources
Physiological cellular reprogramming and cancer
Seminars in Cancer Biology, 2010The traditional approaches to cancer research and therapy have been primarily focused in the aspect of aberrant, uncontrolled, proliferation. Although this is clearly a very important issue, however, the emphasis on this characteristic has led to a relative neglect of an essential aspect of cancer biology: the alteration of normal differentiation ...
Abollo-Jiménez, Fernando +2 more
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Detecting Cellular Senescence in Reprogramming
2018Cellular senescence has been suggested to facilitate tissue regeneration via promoting cellular plasticity. Here, we describe multiple systems, both in vitro and in vivo, to detect senescence in the context of cellular reprogramming.
Cazin, Coralie +2 more
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Debugging cellular reprogramming
Nature Cell Biology, 2007Last year it was reported that a cocktail of four transcription factors — encoded by Oct4, Sox2, Myc and Klf4 — can partly reprogramme mouse somatic cells to an embryonic state, a process that reawakens silenced segments of the genome and restores pluripotency to the somatic cell nucleus.
In-Hyun Park, George Q. Daley
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Therapeutic Cloning and Cellular Reprogramming
2012Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection.
Ramon M, Rodriguez +2 more
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Cellular Reprogramming and Aging
2020In this chapter, we will discuss how aging impacts the dynamics of stem cells and affects cellular reprogramming. We will discuss certain pathways involved in the aging process, and how we can use those pathways to increase the efficiency of the reprogramming protocol.
Sandrina Nóbrega-Pereira +1 more
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