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Physiological cellular reprogramming and cancer
Seminars in Cancer Biology, 2010 The traditional approaches to cancer research and therapy have been primarily focused in the aspect of aberrant, uncontrolled, proliferation. Although this is clearly a very important issue, however, the emphasis on this characteristic has led to a relative neglect of an essential aspect of cancer biology: the alteration of normal differentiation ...
Abollo-Jiménez, Fernando +2 more
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The crosstalk between cellular reprogramming and senescence in aging and regeneration
Experimental Gerontology, 2020 International audienceAging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible.
Han Li
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The Ethics of Cellular Reprogramming
Cellular Reprogramming, 2023Louise Brown's birth in 1978 heralded a new era not just in reproductive technology, but in the relationship between science, cells, and society. For the first time, human embryos could be created, selected, studied, manipulated, frozen, altered, or destroyed, outside the human body. But with this possibility came a plethora of ethical questions. Is it
Anna Smajdor, Adrian Villalba
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Engineering cell fate: Applying synthetic biology to cellular reprogramming
Current Opinion in Systems Biology, 2020 Cellular reprogramming drives cells from one stable identity to a new cell fate. By generating a diversity of previously inaccessible cell types from diverse genetic backgrounds, cellular reprogramming is rapidly transforming how we study disease ...
Adam Beitz, Nat B Wang
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Molecular features of cellular reprogramming and development [PDF]
Nature Reviews Molecular Cell Biology, 2016 Differentiating somatic cells are progressively restricted to specialized functions during ontogeny, but they can be experimentally directed to form other cell types, including those with complete embryonic potential. Early nuclear reprogramming methods,
Alexander Meissner, Zachary Smith
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Implications of Cellular Aging in Cardiac Reprogramming [PDF]
Frontiers in Cardiovascular Medicine, 2018 Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfunction over time, representing a risk factor for diseases development, including cardiovascular.
Gianluca Testa, Fabiana Passaro
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SOX17 in cellular reprogramming and cancer
Seminars in Cancer Biology, 2020SOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the cardiovascular system and several endoderm-derived organs. The analysis of cancer genome sequencing data classified SOX17 as mutated cancer driver gene in endometrial ...
Daisylyn Senna, Tan +4 more
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2006
The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
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The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
openaire +2 more sources
Therapeutic Cloning and Cellular Reprogramming
2012Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection.
Ramon M, Rodriguez +2 more
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Cellular Reprogramming and Aging
2020In this chapter, we will discuss how aging impacts the dynamics of stem cells and affects cellular reprogramming. We will discuss certain pathways involved in the aging process, and how we can use those pathways to increase the efficiency of the reprogramming protocol.
Sandrina Nóbrega-Pereira +1 more
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