Results 271 to 280 of about 233,840 (301)
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Therapeutic Cloning and Cellular Reprogramming
2012Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection.
Ramon M, Rodriguez +2 more
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Cellular Reprogramming and Aging
2020In this chapter, we will discuss how aging impacts the dynamics of stem cells and affects cellular reprogramming. We will discuss certain pathways involved in the aging process, and how we can use those pathways to increase the efficiency of the reprogramming protocol.
Sandrina Nóbrega-Pereira +1 more
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The expanding horizon of MicroRNAs in cellular reprogramming
Progress in Neurobiology, 2017Research over the last few years in cellular reprogramming has enlightened the magical potential of microRNAs (miRNAs) in changing the cell fate from somatic to pluripotent. Recent investigations on exploring the role(s) of miRNAs in somatic cell reprogramming revealed that they target a wide range of molecules and refine their protein output.
Yogita K, Adlakha, Pankaj, Seth
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Cellular reprogramming to reset epigenetic signatures
Molecular Aspects of Medicine, 2013The controlled differentiation of induced pluripotent stem cells (iPSC) towards clinically-relevant cell types has benefitted from epigenetic profiling of lineage-specific markers to confirm the phenotype of iPSC-derived cells. Mapping epigenetic marks throughout the genome has identified unique changes which occur in the DNA methylation profile of ...
Kyle J, Hewitt, Jonathan A, Garlick
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Cellular Reprogramming in the Retina — Seeing the Light
New England Journal of Medicine, 2018Eyeing Up Retinal Plasticity Depletion of retinal neurons underlies various forms of vision loss. A recent study of a mouse model showed that a retinal glial cell can be coaxed into assuming retinal neuron identity and function.
Yi, Lu, Kang, Zhang
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High-efficiency cellular reprogramming with microfluidics
Nature Methods, 2016We report that the efficiency of reprogramming human somatic cells to induced pluripotent stem cells (hiPSCs) can be dramatically improved in a microfluidic environment. Microliter-volume confinement resulted in a 50-fold increase in efficiency over traditional reprogramming by delivery of synthetic mRNAs encoding transcription factors.
LUNI, CAMILLA +10 more
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Small Molecules in Cellular Reprogramming and Differentiation
2010Recent advances in somatic cell reprogramming and directed differentiation make it possible to generate patient-specific pluripotent cells and further derive functional tissue-specific cells for biomedical research and future therapies. Chemical compounds targeting enzymes or signaling proteins are powerful tools to regulate and reveal complex cellular
Xu, Yuan, Wenlin, Li, Sheng, Ding
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The Cellular Memory Disc of Reprogrammed Cells
Stem Cell Reviews and Reports, 2013The crucial facts underlying the low efficiency of cellular reprogramming are poorly understood. Cellular reprogramming occurs in nuclear transfer, induced pluripotent stem cell (iPSC) formation, cell fusion, and lineage-switching experiments. Despite these advances, there are three fundamental problems to be addressed: (1) the majority of cells cannot
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Cellular Reprogramming During Mouse Development
2012States of terminal cell differentiation are often considered to be fixed. There are examples, however, in which cells of one type can be converted to a completely different cell type. The process whereby one cell type can be converted to another is referred to as cellular reprogramming.
Zoë D, Burke +2 more
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The mystique of cellular reprogramming
Current Opinion in Genetics & Development, 2013Huck Hui, Ng, Patrick P L, Tam
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